Adagrasib (MRTX849)

目录号：S8884 批次号：S888401

化学数据

	别名	N/A	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₃₂H₃₅ClFN₇O₂
	分子量	604.12	CAS号	2326521-71-3
Solubility (25°C)*	体外	DMSO	100 mg/mL (165.53 mM)
		Ethanol	50 mg/mL (82.76 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

Adagrasib (MRTX849) 是一种有效的，选择性的和共价的KRAS G12C抑制剂，具有良好的药物样特性，可选择性地修饰GDP结合的KRAS G12C中的突变半胱氨酸12并抑制KRAS依赖性信号传导。

靶点

K-Ras(G12C) ^[1]

参考文献

[1] Jill Hallin,et al.Cancer Discov.2020;10 (1): 54-71.

Adagrasib (MRTX849)在文献中得到引用

Base editing screens define the genetic landscape of cancer drug resistance mechanisms [ Nat Genet, 2024, 10.1038/s41588-024-01948-8]	PubMed: 39424923
Combined inhibition of KRASG12C and mTORC1 kinase is synergistic in non-small cell lung cancer [ Nat Commun, 2024, 15(1):6076]	PubMed: 39025835
Targeted therapies prime oncogene-driven lung cancers for macrophage-mediated destruction [ J Clin Invest, 2024, 134(9)e169315]	PubMed: 38483480
AXL signal mediates adaptive resistance to KRAS G12C inhibitors in KRAS G12C-mutant tumor cells [ Cancer Lett, 2024, 587:216692]	PubMed: 38342232
WEE1 confers resistance to KRASG12C inhibitors in non-small cell lung cancer [ Cancer Lett, 2024, 611:217414]	PubMed: 39725152
SRC kinase drives multidrug resistance induced by KRAS-G12C inhibition [ Sci Adv, 2024, 10(50):eadq4274]	PubMed: 39661665
ADT-1004: A First-in-Class, Orally Bioavailable Selective pan-RAS Inhibitor for Pancreatic Ductal Adenocarcinoma [ bioRxiv, 2024, 2024.10.04.616725]	PubMed: 39416034
Blocking Genomic Instability Prevents Acquired Resistance to MAPK Inhibitor Therapy in Melanoma [ Cancer Discov, 2023, 13(4):880-909]	PubMed: 36700848
Anticancer Efficacy of KRASG12C Inhibitors Is Potentiated by PAK4 Inhibitor KPT9274 in Preclinical Models of KRASG12C-Mutant Pancreatic and Lung Cancers [ Mol Cancer Ther, 2023, 22(12):1422-1433]	PubMed: 37703579
Targeted therapies prime oncogene-driven lung cancers for macrophage-mediated destruction [ bioRxiv, 2023, 2023.03.03.531059]	PubMed: 36945559

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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