NAK/TBK1 (N-term) Rabbit Recombinant mAb

生物描述

特异性

NAK/TBK1 (N-term) Rabbit Recombinant mAb detects endogenous level of total NAK/TBK1 (N-term).

背景

TANK Binding Kinase 1 (TBK1) is an IKK (IκB Kinase)-related kinase that is activated by phosphorylation of Serine-172 by TLR and RIG1 signalling, and this circuit triggers phosphorylation of IRF3 and IRF7, activation of NFκB and the expression of proinflammatory genes and interferons. In addition to the crucial role TBK1 plays in regulating innate immunity, TBK1 also participates in pathways leading to survival and cellular transformation. It has a major role in autophagy and mitophagy, chiefly the phosphorylation of autophagy adaptors. TBK1 is required for efficient cargo recruitment in autophagy.

使用信息

抗体应用	WB, IHC, IF,ELISA,ELISA
稀释比例	WB IHC IF 1:1000 1:50 1:50
反应性	Human Mouse Rat
MW (kDa)	84kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Pillai S, et al. Nat Commun. 2015, 6:10072. [2] James A. Oakes, et al. Molecular Brain. 2017, 10:5.

Application Data

WB

IHC

IF