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特异性 | NEFH Rabbit Recombinant mAb detects endogenous level of total NEFH. |
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背景 | Neurofilaments (NFs) are intermediate filaments with a diameter of 10 nm, similar to that of neurons. Although they are present in perikarya and dendrites, neurofilaments are particularly abundant in axons, where they are essential for the radial growth of axons during development, the maintenance of axon caliber and the transmission of electrical impulses along axons, i.e. velocity of nerve conduction. Neurofilaments from the central nervous system (CNS) are heteropolymers that are composed of four subunits, namely neurofilament heavy, medium and light polypeptides (NFH, NFM and NFL, respectively; also known as NEFH, NEFM and NEFL), as well as α-internexin (Int), whereas in the peripheral nervous system, neurofilaments are made up of NFH, NFM, NFL and peripherin. |
抗体应用 | WB, IHC,ELISA,ELISA | ||||
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稀释比例 |
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反应性 | Human Mouse Rat | ||||
MW (kDa) | 200kDa | ||||
抗体类型 | Rabbit | ||||
储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||||
储存条件 (自收到货起) |
Store at –20°C. |
WB
Validated by Selleck
IHC
Validated by Selleck