生物描述

特异性

NFAT2 Rabbit Recombinant mAb detects endogenous levels of total NFAT2.

背景

The NFAT (nuclear factor of activated T cells) family of transcription factors have crucial roles in the development and function of the immune system. In T cells, NFAT proteins not only regulate activation but also are involved in the control of thymocyte development, T-cell differentiation and selftolerance. The NFAT family consists of five members: NFAT1 (also known as NFATp or NFATc2), NFAT2 (also known as NFATc or NFATc1), NFAT3 (also known as NFATc4), NFAT4 (also known as NFATx or NFATc3) and NFAT5. The main mode of NFAT regulation is through calcium and calcineurin. In addition, NFAT2 is also regulated at the transcriptional level through an autoregulatory loop. NFAT1, NFAT2 and NFAT4 are all co-expressed in T cells and are activated in response to TCR engagement.

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human
MW (kDa)	101kDa
抗体类型
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Macian F. Nat Rev Immunol. 2005, 5(6):472-84.

Application Data

WB

IF