Nigericin sodium salt

目录号：S6653 批次号：S665301

化学数据

	别名	NSC 292567	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₄₀H₆₇NaO₁₁
	分子量	746.94	CAS号	28643-80-3
Solubility (25°C)*	体外	Ethanol	100 mg/mL (133.87 mM)
		DMSO	Insoluble
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

Nigericin sodium salt是从Streptomyces hygroscopicus衍生的抗生素，通过充当H⁺，K⁺和Pb²⁺的离子载体起作用。Nigericin可以激活NLRP3炎性体以诱导促炎和免疫刺激过程。

靶点

Potassium channel ^[1]

Hydrogen channel ^[1]

Pb 2+ ^[1]

NLRP3 ^[2]

参考文献

Nigericin sodium salt在文献中得到引用

NINJ1 regulates plasma membrane fragility under mechanical strain [ Nature, 2025, 10.1038/s41586-025-09222-5]	PubMed: 40490006
PM2.5 exacerbates nasal epithelial barrier dysfunction in allergic rhinitis by inducing NLRP3-mediated pyroptosis via the AhR/CYP1A1/ROS axis [ J Hazard Mater, 2025, 492:138145]	PubMed: 40209413
ALIX mediates reversible gasdermin-D pore formation via the endosomal pathway to limit pyroptosis by active membrane repair [ Cell Death Dis, 2025, 16(1):681]	PubMed: 41053117
Targeting RPLP2 Triggers DLBCL Ferroptosis by Decreasing FXN Expression [ Biomedicines, 2025, 13(6)1320]	PubMed: 40564039
GPR34 Stabilized by Deubiquitinase USP8 Suppresses Ferroptosis of ATC [ Mediators Inflamm, 2025, 2025:5576056]	PubMed: 40862294
Human cytomegalovirus protein US18 promotes NLRP3 inflammasome activation [ Biochem Biophys Res Commun, 2025, 775:152110]	PubMed: 40450990
Small nuclear ribonucleoprotein polypeptide B2 regulated by SNHG4/miR-204-5p axis inhibits ferroptosis to aggravate the progression of hepatocellular carcinoma [ Discov Oncol, 2025, 16(1):1349]	PubMed: 40670855
Chinese medicinal formula Fu Xin decoction against chronic heart failure by inhibiting the NLRP3/caspase-1/GSDMD pyroptotic pathway [ Biomed Pharmacother, 2024, 174:116548]	PubMed: 38599064
Pre-treatment with notoginsenoside R1 from Panax notoginseng protects against high-altitude-induced pulmonary edema by inhibiting pyroptosis through the NLRP3/caspase-1/GSDMD pathway [ Biomed Pharmacother, 2024, 180:117512]	PubMed: 39353320
Methionine deficiency inhibited pyroptosis in primary hepatocytes of grass carp (Ctenopharyngodon idella): possibly via activating the ROS-AMPK-autophagy axis [ J Anim Sci Biotechnol, 2024, 15(1):116]	PubMed: 39218924

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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