Nigericin sodium salt

目录号：S6653 批次号：S665303

化学数据

	别名	NSC 292567	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₄₀H₆₇NaO₁₁
	分子量	746.94	CAS号	28643-80-3
Solubility (25°C)*	体外	Ethanol	100 mg/mL (133.87 mM)
		DMSO	Insoluble
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

Nigericin sodium salt是从Streptomyces hygroscopicus衍生的抗生素，通过充当H⁺，K⁺和Pb²⁺的离子载体起作用。Nigericin可以激活NLRP3炎性体以诱导促炎和免疫刺激过程。

靶点

Potassium channel ^[1]

Hydrogen channel ^[1]

Pb 2+ ^[1]

NLRP3 ^[2]

参考文献

Nigericin sodium salt在文献中得到引用

3'-Deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome [ Neural Regen Res, 2024, 19(10):2270-2280]	PubMed: 38488561
ER stress induces caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with herpes simplex virus type 2 [ EMBO J, 2023, e113118.]	PubMed: 37646198
Lipocalin-2-mediated astrocyte pyroptosis promotes neuroinflammatory injury via NLRP3 inflammasome activation in cerebral ischemia/reperfusion injury [ J Neuroinflammation, 2023, 20(1):148]	PubMed: 37353794
Stellate ganglion block ameliorated central post-stroke pain with comorbid anxiety and depression through inhibiting HIF-1α/NLRP3 signaling following thalamic hemorrhagic stroke [ J Neuroinflammation, 2023, 20(1):82]	PubMed: 36944982
A novel sorbicillinoid compound as a potent anti-inflammation agent through inducing NLRP3 protein degradation [ Br J Pharmacol, 2023, 10.1111/bph.16058]	PubMed: 36788033
Takinib inhibits microglial M1 polarization and oxidative damage after subarachnoid hemorrhage by targeting TAK1-dependent NLRP3 inflammasome signaling pathway [ Front Immunol, 2023, 14:1266315]	PubMed: 38035075
Eleutheroside E from pre-treatment of Acanthopanax senticosus (Rupr.etMaxim.) Harms ameliorates high-altitude-induced heart injury by regulating NLRP3 inflammasome-mediated pyroptosis via NLRP3/caspase-1 pathway [ Int Immunopharmacol, 2023, 121:110423]	PubMed: 37331291
Sipeimine attenuates PM2.5-induced lung toxicity via suppression of NLRP3 inflammasome-mediated pyroptosis through activation of the PI3K/AKT pathway [ Chem Biol Interact, 2023, 376:110448]	PubMed: 36898572
Electroacupuncture improves gout arthritis pain via attenuating ROS-mediated NLRP3 inflammasome overactivation [ Chin Med, 2023, 18(1):86]	PubMed: 37464384
Salidroside pretreatment alleviates PM2.5 caused lung injury via inhibition of apoptosis and pyroptosis through regulating NLRP3 Inflammasome [ Food Chem Toxicol, 2023, 177:113858]	PubMed: 37236293

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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