Nilotinib hydrochloride monohydrate

目录号：S4895 批次号：S489501

化学数据

	别名	Tasigna, AMN-107 hydrochloride monohydrate	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₂₈H₂₅ClF₃N₇O₂
	分子量	583.99	CAS号	923288-90-8
Solubility (25°C)*	体外	DMSO	100 mg/mL (171.23 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

Nilotinib (AMN-107, Tasigna) hydrochloride monohydrate 是一种选择性的 Bcr-Abl 的口服生物利用抑制剂，在鼠骨髓祖细胞中的IC50值小于30 nM。Nilotinib 通过 AMPK 激活来诱导自噬。

靶点

AMPK ^[1]	Bcr-Abl ^[1] (in Murine myeloid progenitor cells)
	30 nM

参考文献

[1] Ellen Weisberg, et al. Blood. 2007 Mar 1;109(5):2112-20.

Nilotinib hydrochloride monohydrate在文献中得到引用

Comprehensive multi-omics analysis reveals WEE1 as a synergistic lethal target with hyperthermia through CDK1 super-activation [ Nat Commun, 2024, 15(1):2089]	PubMed: 38453961
Preclinical Evaluation of Ixabepilone in Combination with VEGF Receptor and PARP Inhibitors in Taxane-Sensitive and Taxane-Resistant MDA-MB-231 Breast Cancer Cells [ J Pharm Sci, 2022, 111(8):2180-2190]	PubMed: 35700798
Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix-mediated tumor cell adaptation and tolerance to BRAF-targeted therapy in melanoma [ EMBO Mol Med, 2021, e11814]	PubMed: 34957688
Antimetabolic cooperativity with the clinically approved l-asparaginase and tyrosine kinase inhibitors to eradicate CML stem cells [ Mol Metab, 2021, 55:101410]	PubMed: 34863941
CXCR2, a novel target to overcome tyrosine kinase inhibitor resistance in chronic myelogenous leukemia cells [ Biochem Pharmacol, 2021, 190:114658]	PubMed: 34146540
Imatinib can act as an Allosteric Activator of Abl Kinase [ J Mol Biol, 2021, 434(2):167349]	PubMed: 34774565
Statins Enhance the Molecular Response in Chronic Myeloid Leukemia when Combined with Tyrosine Kinase Inhibitors [ Cancers (Basel), 2021, 13(21)5543]	PubMed: 34771705
ABL1 and Cofilin1 promote T-cell acute lymphoblastic leukemia cell migration [ Acta Biochim Biophys Sin (Shanghai), 2021, gmab117]	PubMed: 34508625
Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1T315I and BCR-ABL1T315I-E255K [ Ann Hematol, 2021, 10.1007/s00277-020-04357-z]	PubMed: 34110462
Modulation of leukotriene signaling inhibiting cell growth in chronic myeloid leukemia [ Leuk Lymphoma, 2017, 58(8):1903-1913]	PubMed: 27931141

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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