Nivolumab (anti-PD-1)

目录号：A2002         批次号: A200206

打印

Nivolumab (anti-PD-1)是一种通过基因工程改造的、人类免疫球蛋白(Ig)G4单克隆抗体，靶向具有负向免疫调节功能的人类细胞表面受体程序性死亡-1（PD-1, PCD-1）；也是一种抑制剂，具有免疫检查点抑制活性和抗肿瘤活性；MW：143.597 KD。

抗体信息

CAS号 946414-94-4
配制 PBS buffer, pH 7.2
推荐同型对照 Human IgG4
来源 CHO cells
储存条件
(自收到货起)		 Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
纯度 99.52%
蛋白浓度 4.95mg/ml
内毒素 ≤1 EU/mg

客户使用selleck产品的实验数据

数据来源于[Data independently produced by , , Clin Cancer Res, 2019, doi:10.1158/1078-0432]

Apoptosis rates of Jurkat cells co-cultured for 72 h with H1975, A549 cells or H1975 with 10 μg/mL nivolumab were analyzed by Annexin V-FITC/PI assay (Left) and quantified (Right).

数据来源于[Data independently produced by , , Ann Surg Oncol, 2019, 26(1):139-147]

Preliminary immunotherapy drug screening using immune checkpoint inhibitors pembrolizumab and nivolumab in LGA organoids immune-enhanced with cells from a lymph node from the same patient. Mitochondrial metabolism was assessed at (c) 24 h and (d) 96 h after administration of the immunotherapy agents. Statistical significance: **p<0.05 between tumor cell-only and immune-enhanced organoids; p<0.05 between drug treatment and control of the same group.

Nivolumab (anti-PD-1)在文献中得到引用

Genomic and transcriptomic profiling of peripheral T cell lymphoma reveals distinct molecular and microenvironment subtypes [ Cell Rep Med, 2024, 5(2):101416] PubMed: 38350451
NKG2A+CD8+ T cells infiltration determines immunosuppressive contexture and inferior response to immunotherapy in clear cell renal cell carcinoma [ J Immunother Cancer, 2024, 12(1)e008368] PubMed: 38262706
[ Transl Oncol, 2024, ] PubMed: 38412661
Tumor associated neutrophils governs tumor progression through an IL-10/STAT3/PD-L1 feedback signaling loop in lung cancer [ Transl Oncol, 2024, 40:101866] PubMed: 38128466
Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors [ Life Sci Alliance, 2024, 7(3)e202302368] PubMed: 38176728
A murine model to evaluate immunotherapy effectiveness for human Fanconi anemia-mutated acute myeloid leukemia [ PLoS One, 2024, 19(1):e0292375] PubMed: 38289944
Acquired resistance to CDK4/6 inhibition is associated with dysregulation of multiple pathways including cyclin D-CDK4/6-RB, EGFR/HER, AKT/mTOR and IFN [ Research Square, 2024, 10.21203/rs.3.rs-3782509/v1] PubMed: none
Base editing screens map mutations affecting interferon-γ signaling in cancer [ Cancer Cell, 2023, S1535-6108(22)00595-5] PubMed: 36669486
Low-dose carboplatin modifies the tumor microenvironment to augment CAR T cell efficacy in human prostate cancer models [ Nat Commun, 2023, 14(1):5346] PubMed: 37660083
Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche [ Nat Commun, 2023, 14(1):2685] PubMed: 37164949

禁止用于人体及治疗！