全国免费电话:400-668-6834 -- 仅限中国地区 -- |
在线订购:QQ: 4006686834 电话订购:021-68591985 邮件订购:info@selleck.cn 我们也提供销售人员上门服务 |
技术支持电话:400-168-6834 我们将于一个工作日与您联系 |
目录号:A2002 批次号: A200207
Nivolumab (anti-PD-1)是一种通过基因工程改造的、人类免疫球蛋白(Ig)G4单克隆抗体,靶向具有负向免疫调节功能的人类细胞表面受体程序性死亡-1(PD-1, PCD-1);也是一种抑制剂,具有免疫检查点抑制活性和抗肿瘤活性;MW:143.597 KD。
CAS号 | 946414-94-4 |
---|---|
配制 | PBS buffer, pH 7.2 |
推荐同型对照 | Human IgG4 |
来源 | CHO cells |
储存条件 (自收到货起) |
Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles |
纯度 | 99.87% |
蛋白浓度 | 8.8 mg/ml |
内毒素 | <1 EU/mg |
数据来源于[Data independently produced by , , Clin Cancer Res, 2019, doi:10.1158/1078-0432]
Apoptosis rates of Jurkat cells co-cultured for 72 h with H1975, A549 cells or H1975 with 10 μg/mL nivolumab were analyzed by Annexin V-FITC/PI assay (Left) and quantified (Right).
数据来源于[Data independently produced by , , Ann Surg Oncol, 2019, 26(1):139-147]
Preliminary immunotherapy drug screening using immune checkpoint inhibitors pembrolizumab and nivolumab in LGA organoids immune-enhanced with cells from a lymph node from the same patient. Mitochondrial metabolism was assessed at (c) 24 h and (d) 96 h after administration of the immunotherapy agents. Statistical significance: **p<0.05 between tumor cell-only and immune-enhanced organoids; p<0.05 between drug treatment and control of the same group.
Clinical drug screening reveals clofazimine potentiates the efficacy while reducing the toxicity of anti-PD-1 and CTLA-4 immunotherapy [ Cancer Cell, 2024, S1535-6108(24)00080-1] | PubMed: 38518774 |
Genomic and transcriptomic profiling of peripheral T cell lymphoma reveals distinct molecular and microenvironment subtypes [ Cell Rep Med, 2024, 5(2):101416] | PubMed: 38350451 |
NKG2A+CD8+ T cells infiltration determines immunosuppressive contexture and inferior response to immunotherapy in clear cell renal cell carcinoma [ J Immunother Cancer, 2024, 12(1)e008368] | PubMed: 38262706 |
[ Transl Oncol, 2024, ] | PubMed: 38412661 |
Tumor associated neutrophils governs tumor progression through an IL-10/STAT3/PD-L1 feedback signaling loop in lung cancer [ Transl Oncol, 2024, 40:101866] | PubMed: 38128466 |
Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors [ Life Sci Alliance, 2024, 7(3)e202302368] | PubMed: 38176728 |
A murine model to evaluate immunotherapy effectiveness for human Fanconi anemia-mutated acute myeloid leukemia [ PLoS One, 2024, 19(1):e0292375] | PubMed: 38289944 |
Acquired resistance to CDK4/6 inhibition is associated with dysregulation of multiple pathways including cyclin D-CDK4/6-RB, EGFR/HER, AKT/mTOR and IFN [ Research Square, 2024, 10.21203/rs.3.rs-3782509/v1] | PubMed: none |
Base editing screens map mutations affecting interferon-γ signaling in cancer [ Cancer Cell, 2023, S1535-6108(22)00595-5] | PubMed: 36669486 |
Low-dose carboplatin modifies the tumor microenvironment to augment CAR T cell efficacy in human prostate cancer models [ Nat Commun, 2023, 14(1):5346] | PubMed: 37660083 |
禁止用于人体及治疗!