Nivolumab (anti-PD-1)

目录号：A2002         批次号: A200209

打印

Nivolumab (anti-PD-1)是一种通过基因工程改造的、人类免疫球蛋白(Ig)G4单克隆抗体，靶向具有负向免疫调节功能的人类细胞表面受体程序性死亡-1（PD-1, PCD-1）；也是一种抑制剂，具有免疫检查点抑制活性和抗肿瘤活性；MW：143.597 KD。

抗体信息

CAS号 946414-94-4
配制 100 mM Pro-Ac, 20 mM Arg, pH5.0
推荐同型对照 Human IgG4
来源 CHO cells
储存条件
(自收到货起)		 Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
纯度 99%
蛋白浓度 10.84mg/ml
内毒素 ＜1EU/mg

客户使用selleck产品的实验数据

数据来源于[Data independently produced by , , Clin Cancer Res, 2019, doi:10.1158/1078-0432]

Apoptosis rates of Jurkat cells co-cultured for 72 h with H1975, A549 cells or H1975 with 10 μg/mL nivolumab were analyzed by Annexin V-FITC/PI assay (Left) and quantified (Right).

数据来源于[Data independently produced by , , Ann Surg Oncol, 2019, 26(1):139-147]

Preliminary immunotherapy drug screening using immune checkpoint inhibitors pembrolizumab and nivolumab in LGA organoids immune-enhanced with cells from a lymph node from the same patient. Mitochondrial metabolism was assessed at (c) 24 h and (d) 96 h after administration of the immunotherapy agents. Statistical significance: **p<0.05 between tumor cell-only and immune-enhanced organoids; p<0.05 between drug treatment and control of the same group.

Nivolumab (anti-PD-1)在文献中得到引用

Analysis of tumor-infiltrating exhausted T cells highlights IL-6 and PD1 blockade as a combined immunotherapy strategy for non-small cell lung cancer [ Front Immunol, 2025, 16:1486329] PubMed: 40040705
Therapeutic effect of fully human anti-Nrp-1 antibody on non-small cell lung cancer in vivo and in vitro [ Cancer Immunol Immunother, 2025, 74(2):50] PubMed: 39751948
NSUN2/ALYREF axis-driven m5C methylation enhances PD-L1 expression and facilitates immune evasion in non-small-cell lung cancer [ Cancer Immunol Immunother, 2025, 74(4):132] PubMed: 40029463
Protocol for a patient-derived preclinical platform to model tumor-immune interactions and evaluate therapeutic efficacy [ STAR Protoc, 2025, 6(1):103623] PubMed: 39918963
Clinical drug screening reveals clofazimine potentiates the efficacy while reducing the toxicity of anti-PD-1 and CTLA-4 immunotherapy [ Cancer Cell, 2024, S1535-6108(24)00080-1] PubMed: 38518774
Base editing screens define the genetic landscape of cancer drug resistance mechanisms [ Nat Genet, 2024, 10.1038/s41588-024-01948-8] PubMed: 39424923
Human papillomavirus-encoded circular RNA circE7 promotes immune evasion in head and neck squamous cell carcinoma [ Nat Commun, 2024, 15(1):8609] PubMed: 39366979
Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer [ J Exp Med, 2024, 221(10)e20240152] PubMed: 39190534
Assessing personalized responses to anti-PD-1 treatment using patient-derived lung tumor-on-chip [ Cell Rep Med, 2024, S2666-3791(24)00241-6] PubMed: 38703767
Modeling lung adenocarcinoma metastases using patient-derived organoids [ Cell Rep Med, 2024, 5(10):101777] PubMed: 39413736

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