Nivolumab (anti-PD-1)

目录号：A2002         批次号: A200211

打印

Nivolumab (anti-PD-1)是一种通过基因工程改造的、人类免疫球蛋白(Ig)G4单克隆抗体，靶向具有负向免疫调节功能的人类细胞表面受体程序性死亡-1（PD-1, PCD-1）；也是一种抑制剂，具有免疫检查点抑制活性和抗肿瘤活性；MW：143.597 KD。

抗体信息

CAS号 946414-94-4
配制 100 mM Pro-Ac, 20 mM Arg, pH5.0
推荐同型对照 Human IgG4
来源 CHO cells
储存条件
(自收到货起)		 Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
除菌 0.2 μM filtered
纯度 99%
蛋白浓度 10.796mg/ml
内毒素 ＜1EU/mg

客户使用selleck产品的实验数据

数据来源于[Data independently produced by , , Clin Cancer Res, 2019, doi:10.1158/1078-0432]

Apoptosis rates of Jurkat cells co-cultured for 72 h with H1975, A549 cells or H1975 with 10 μg/mL nivolumab were analyzed by Annexin V-FITC/PI assay (Left) and quantified (Right).

数据来源于[Data independently produced by , , Ann Surg Oncol, 2019, 26(1):139-147]

Preliminary immunotherapy drug screening using immune checkpoint inhibitors pembrolizumab and nivolumab in LGA organoids immune-enhanced with cells from a lymph node from the same patient. Mitochondrial metabolism was assessed at (c) 24 h and (d) 96 h after administration of the immunotherapy agents. Statistical significance: **p<0.05 between tumor cell-only and immune-enhanced organoids; p<0.05 between drug treatment and control of the same group.

Nivolumab (anti-PD-1)在文献中得到引用

Macrophages regulate PD-1 and CTLA-4 expression on ILC2s and their responsiveness in the tumor microenvironment [ Cell Mol Immunol, 2025, 22(11):1491-1505] PubMed: 40993215
Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of adoptive Delta One T cell therapy against colorectal cancer [ Nat Cancer, 2025, 10.1038/s43018-025-00948-9] PubMed: 40240620
In situ and dynamic screening of extracellular vesicles as predictive biomarkers in immune-checkpoint inhibitor therapies [ J Nanobiotechnology, 2025, 23(1):411] PubMed: 40457452
A Phosphatidylinositol 3-Kinase Gamma Inhibitor Enhances Anti-Programmed Death-1/Programmed Death Ligand-1 Antitumor Effects by Remodeling the Tumor Immune Microenvironment of Ovarian Cancer [ MedComm (2020), 2025, 6(8):e70223] PubMed: 40703194
Arsenic sulfide enhances the therapeutic effect of hepatocellular carcinoma immunotherapy through STAT3-THBS1/CD47 pathway [ Front Immunol, 2025, 16:1612318] PubMed: 41019041
Analysis of tumor-infiltrating exhausted T cells highlights IL-6 and PD1 blockade as a combined immunotherapy strategy for non-small cell lung cancer [ Front Immunol, 2025, 16:1486329] PubMed: 40040705
Therapeutic effect of fully human anti-Nrp-1 antibody on non-small cell lung cancer in vivo and in vitro [ Cancer Immunol Immunother, 2025, 74(2):50] PubMed: 39751948
NSUN2/ALYREF axis-driven m5C methylation enhances PD-L1 expression and facilitates immune evasion in non-small-cell lung cancer [ Cancer Immunol Immunother, 2025, 74(4):132] PubMed: 40029463
Sprinkling in extra validation for high-value PTMs and therapeutic Abs with MILKSHAKE Western blots and Sundae ELISAs [ N Biotechnol, 2025, 89:11-19] PubMed: 40482963
Biofabrication of pheochromocytoma and paraganglioma tumor organoids and assessment of response to systemic therapy [ Sci Rep, 2025, 15(1):35889] PubMed: 41087622

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