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别名 | RG 6078, NLG-919 analogue, GDC-0919 analogue | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
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化学式 | C18H22N2O |
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分子量 | 282.38 | CAS号 | 1402836-58-1 | ||||
Solubility (25°C)* | 体外 | Ethanol | 56 mg/mL (198.31 mM) | ||||
DMSO | 15 mg/mL (53.11 mM) | ||||||
Water | Insoluble | ||||||
体内 (现配现用) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | IDO-IN-2 (RG 6078, NLG-919 analogue, GDC-0919 analogue)是一种有效的 IDO1 通路抑制剂,IC50值 of 38 nM。 | ||
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靶点 |
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数据来源于[, 10.1177/1087057114536616]
数据来源于[Data independently produced by , , Biochem Pharmacol, 2018, 158:286-297]
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Cascade Immune Activation of Self-Delivery Biomedicine for Photodynamic Immunotherapy Against Metastatic Tumor [ Small, 2022, e2205694] | PubMed: 36366925 |
Downregulation of miR-26 promotes invasion and metastasis via targeting interleukin-22 in cutaneous T-cell lymphoma [ Int J Mol Sci, 2022, 23(7)3981] | PubMed: 35409342 |
Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation [ J Immunother Cancer, 2021, 9(7)e002840] | PubMed: 34326168 |
Decreased IDO1 Dependent Tryptophan Metabolism in Aged Lung during Influenza [ Eur Respir J, 2020, 2000443] | PubMed: 33243840 |
Ultrasound-Driven Biomimetic Nanosystem Suppresses Tumor Growth and Metastasis through Sonodynamic Therapy, CO Therapy, and Indoleamine 2,3-Dioxygenase Inhibition [ ACS Nano, 2020, 14(7):8985-8999] | PubMed: 32662971 |
Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase 1 (HDAC1) Dual Inhibitors Derived from the Natural Product Saprorthoquinone [ Molecules, 2020, 25(19)E4494] | PubMed: 33007982 |
Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase 1 (HDAC1) Dual Inhibitors Derived from the Natural Product Saprorthoquinone [ Molecules, 2020, 25(19)E4494] | PubMed: 33007982 |
Inhibition of the BET family reduces its new target gene IDO1 expression and the production of L-kynurenine. [ Cell Death Dis, 2019, 10(8):557] | PubMed: 31324754 |
Displacement Induced Off-On Fluorescent Biosensor Targeting IDO1 Activity in Live Cells. [ Anal Chem, 2019, 91(23):14943-14950] | PubMed: 31714063 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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