Nogo Rabbit Recombinant mAb Datasheet

生物描述

特异性	Nogo Rabbit Recombinant mAb detects endogenous level of total Nogo.
背景	Reticulons (Rtn) are a family of proteins that are localized primarily to the endoplasmic reticulon (ER) of most cells. In mammals, there are four family members: Rtn 1, 2, 3, and 4. the Rtn 4 family has three isoforms, named Nogo-A, -B, and -C. Nogo-A is highly expressed in the nervous system and is implicated in controlling axonal regeneration pathways, Nogo-B is expressed in vascular cells and cardiac myocytes in vivo and multiple cell-types in vitro, and Nogo-C is expressed in the nervous system and skeletal muscle cells. Nogo, is an endogenous regulator of inflammatory tissue remodeling and wound healing that is mediated, in part, via impaired macrophage homing to ischemic tissue and wounds in vivo.

特异性

Nogo Rabbit Recombinant mAb detects endogenous level of total Nogo.

背景

Reticulons (Rtn) are a family of proteins that are localized primarily to the endoplasmic reticulon (ER) of most cells. In mammals, there are four family members: Rtn 1, 2, 3, and 4. the Rtn 4 family has three isoforms, named Nogo-A, -B, and -C. Nogo-A is highly expressed in the nervous system and is implicated in controlling axonal regeneration pathways, Nogo-B is expressed in vascular cells and cardiac myocytes in vivo and multiple cell-types in vitro, and Nogo-C is expressed in the nervous system and skeletal muscle cells. Nogo, is an endogenous regulator of inflammatory tissue remodeling and wound healing that is mediated, in part, via impaired macrophage homing to ischemic tissue and wounds in vivo.

使用信息

抗体应用

WB, IHC,ELISA,ELISA

稀释比例

WB	IHC
1:1000	1:50

反应性

Human

MW (kDa)

40-55kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Yu J, et al. Proc Natl Acad Sci U S A. 2009, 106(41):17511-6.

Application Data

WB

Validated by Selleck

IHC

Validated by Selleck