Notch1 Rabbit Recombinant mAb

Notch1 Rabbit Recombinant mAb detects endogenous level of total Notch1.

The Notch signaling pathway is active in all metazoa, with a single receptor present in Drosophila, two in Caenorhabditis elegans and four in mammals. Notch proteins are large transmembrane receptors that become activated by transmembrane ligands of the Delta/Serrate/Lag-2 (DSL) family. The Notch family includes four receptors, NOTCH1, NOTCH2, NOTCH3, and NOTCH4. Oncogenic Ras activates Notch signaling. Wild-type Notch1 is necessary to maintain the neoplastic phenotype in Ras-transformed human cells in vitro and in vivo. The oncogenic effect of NOTCH1 on primary melanoma cells was mediated by beta-catenin, which was upregulated following NOTCH1 activation. Inhibiting beta-catenin expression reversed NOTCH1-enhanced tumor growth and metastasis.