NOX4 Rabbit Recombinant mAb

生物描述

特异性

NOX4 Rabbit Recombinant mAb detects endogenous level of total NOX4.

背景

The reactive oxygen species (ROS)-generating enzyme, NADPH oxidase 4 (Nox4), regulates a number of physiological and pathological processes, including cellular differentiation, host defense and tissue fibrosis. Nox4-mediated oxidative stress has been involved in different cellular processes such as TGF-β1-induced differentiation, cytoskeletal dynamics and transcriptional regulation. The Nox4 isoform is expressed primarily in the mitochondria in cardiac myocytes, thus associates with cardiovascular pathophysiology. Nox4 plays a critical role in mediating mitochondrial dysfunction, apoptosis in cardiac myocytes, and eventual LV dysfunction in response to pressure overload. Additionally, Nox4 has been suggested to regulate urine levels of the metabolite fumarate by controlling the activity of fumarate hydratase. Endogenously expressed Nox4 represses mitochondrial biogenesis.

使用信息

抗体应用	WB, IHC, IF,ELISA,ELISA
稀释比例	WB IHC IF 1:1000 1:50 1:50
反应性	Human Mouse Rat
MW (kDa)	67kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Kuroda J, et al. Proc Natl Acad Sci U S A. 2010, 107(35):15565-70. [2] Karen Bernard, et al. JBC. 2017.

Application Data

WB

IHC

IF