NSD3 Rabbit Recombinant mAb Datasheet

生物描述

特异性	NSD3 Rabbit Recombinant mAb detects endogenous level of total NSD3.
背景	The nuclear receptor binding SET domain (NSD) protein is a family of three HMTases, NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L1, and plays a critical part in chromatin integrity as evidenced by a growing number of conditions linked to the alterations and/or amplification of NSD1, NSD2, and/or NSD3. NSD1, NSD2 and NSD3 are associated with multiple cancers. NSD1 functions in both the retinoic acid receptor (RAR) activation and the lysine degradation pathways. Both NSD2 and NSD3 operate solely in the lysine degradation pathway.

特异性

NSD3 Rabbit Recombinant mAb detects endogenous level of total NSD3.

背景

The nuclear receptor binding SET domain (NSD) protein is a family of three HMTases, NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L1, and plays a critical part in chromatin integrity as evidenced by a growing number of conditions linked to the alterations and/or amplification of NSD1, NSD2, and/or NSD3. NSD1, NSD2 and NSD3 are associated with multiple cancers. NSD1 functions in both the retinoic acid receptor (RAR) activation and the lysine degradation pathways. Both NSD2 and NSD3 operate solely in the lysine degradation pathway.

使用信息

抗体应用

WB, IHC,ELISA,ELISA

稀释比例

WB	IHC
1:1000	1:50

反应性

Human Mouse Rat

MW (kDa)

161kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Morishita M, et al. Biochim Biophys Acta. 2011, 1816(2):158-63.

Application Data

WB

Validated by Selleck

IHC

Validated by Selleck