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特异性 | NUMB Rabbit Recombinant mAb detects endogenous level of total NUMB. |
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背景 | NUMB (protein numb homologue) is the human homologue of the protein numb that was initially discovered in Drosophila melanogaster as an adaptor protein responsible for recruiting proteins into different signalling pathways. NUMB is an evolutionarily conserved protein well-known for its multifaceted role in neurogenesis and cellular homeostasis within the peripheral and central nervous systems. NUMB is a complex protein with multiple cellular functions. It has a prominent role in the control of cell fate within the Hedgehog and p53 signalling pathways. NUMB negatively regulates the NOTCH signalling pathway. Targeting NUMB has potential to control prostate tumorigenesis. |
抗体应用 | WB,ELISA,ELISA | ||
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稀释比例 |
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反应性 | Human Mouse Rat | ||
MW (kDa) | 71kDa | ||
抗体类型 | Rabbit | ||
储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
储存条件 (自收到货起) |
Store at –20°C. |
WB
Validated by Selleck