Datasheet

生物描述

特异性	p53 Rabbit Recombinant mAb detects endogenous levels of total p53.
背景	p53 is a crucial tumor suppressor, long-recognized to suppress cancer through the induction of cell-cycle-arrest or apoptosis programs in response to a plethora of different cellular stress signals. Upon cellular stress signals, such as DNA damage or oncogenic stress, p53 is activated through a cascade of phosphorylation events and other posttranslational modifications (PTMs), resulting in the expression of p53 target genes involved in cell-cycle arrest, DNA repair, or apoptosis, if the damage is irreparable. The p53 target genes also have important roles in senescence, angiogenesis, and autophagy, connecting, for example, p53 and mammalian target of rapamycin (mTOR) signaling.

特异性

p53 Rabbit Recombinant mAb detects endogenous levels of total p53.

背景

p53 is a crucial tumor suppressor, long-recognized to suppress cancer through the induction of cell-cycle-arrest or apoptosis programs in response to a plethora of different cellular stress signals. Upon cellular stress signals, such as DNA damage or oncogenic stress, p53 is activated through a cascade of phosphorylation events and other posttranslational modifications (PTMs), resulting in the expression of p53 target genes involved in cell-cycle arrest, DNA repair, or apoptosis, if the damage is irreparable. The p53 target genes also have important roles in senescence, angiogenesis, and autophagy, connecting, for example, p53 and mammalian target of rapamycin (mTOR) signaling.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human

MW (kDa)

53kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck