PAI1 Rabbit Recombinant mAb

生物描述

特异性

PAI1 Rabbit Recombinant mAb detects endogenous level of total PAI1.

背景

Plasminogen activator inhibitor type-1 (PAI-1) belongs to the serine protease inhibitor (SERPIN) protein family that also includes PAI-2 and PAI-3 (protein C inhibitor), protease nexin-1, and neuroserpin. PAI-1, through its varied interactions with vitronectin and cellular receptors, is centrally positioned to coordinate the duration and locale of both intracellular (signal initiation) and extracellular (detachment/readhesion cycles, receptor binding) events that manage the intricate process of cell movement in both physiologic and pathologic contexts. The binding of PAI-1 with its several targets including VN, uPA, uPA/uPAR, and LRP1 has the potential to affect the motile program on multiple levels providing opportunities to therapeutically manipulate this pathway in pathophysiologic settings.

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human
MW (kDa)	45kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Ralf-Peter Czekay, et al. International Journal of Cell Biology. 2011.

Application Data

WB

IF