Palbociclib

目录号：S4482 批次号：S448203

化学数据

	别名	PD 0332991	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₂₄H₂₉N₇O₂
	分子量	447.53	CAS号	571190-30-2
Solubility (25°C)*	体外	DMSO	Insoluble
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Palbociclib (PD 0332991) 是一种高度特异性的 cyclin-dependent kinase 4 (Cdk4) 和 Cdk6 的抑制剂，IC50值分别为11 nM和16 nM。此产品溶解度不佳，动物体内实验可用，细胞实验请谨慎选择！

靶点

Cdk4 ^[1] (Cell-free assay)	Cdk6 ^[1] (Cell-free assay)
11 nM	16 nM

参考文献

[1] David W Fry, et al. Mol Cancer Ther. 2004 Nov;3(11):1427-38.
[2] Shagisultanova E, et al. Mol Cancer Ther. 2022;21(1):48-57. doi:10.1158/1535-7163.MCT-21-0098

Palbociclib在文献中得到引用

Fasting-mimicking diet potentiates anti-tumor effects of CDK4/6 inhibitors against breast cancer by suppressing NRAS- and IGF1-mediated mTORC1 signaling [ Drug Resist Updat, 2025, 78:101161]	PubMed: 39499997
Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies [ Cell Rep Med, 2025, 6(2):101964]	PubMed: 39933527
Defective homologous recombination and genomic instability predict increased responsiveness to carbon ion radiotherapy in pancreatic cancer [ NPJ Precis Oncol, 2025, 9(1):20]	PubMed: 39824957
Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis [ Elife, 2025, 14e75393]	PubMed: 39791360
Gene expression analysis in circulating tumour cells to determine resistance to CDK4/6 inhibitors plus endocrine therapy in HR + /HER2- metastatic breast cancer patients [ J Transl Med, 2025, 23(1):400]	PubMed: 40186268
CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti-tumoral compounds [ Mol Oncol, 2025, 10.1002/1878-0261.13799]	PubMed: 39776254
Systematic Comparison of FBS and Medium Variation Effect on Key Cellular Processes Using Morphological Profiling [ Cells, 2025, 14(5)336]	PubMed: 40072065
STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair [ Cell, 2024, S0092-8674(24)01200-5]	PubMed: 39547229
Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment [ Cancer Cell, 2024, S1535-6108(24)00037-0]	PubMed: 38402610
Proteogenomic insights into the biology and treatment of pan-melanoma [ Cell Discov, 2024, 10(1):78]	PubMed: 39039072

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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