PARK7 Rabbit Recombinant mAb Datasheet

生物描述

特异性	PARK7 Rabbit Recombinant mAb detects endogenous level of PARK7.
背景	Protein deglycase DJ-1, also known as Parkinson disease protein 7 (PARK7) is a multifunctional protein that plays essential roles in tissues with higher order biological functions such as the testis and brain. DJ-1 has multiple functions: it works as an antioxidant, in transcriptional regulation, as a molecular chaperone and in protein degradation. DJ-1 is located in the cytoplasm, nucleus, and mitochondria in cells, and secreted DJ-1 has been observed in various cultured cells and tissues, including cancer cells and tissues. DJ-1 is translocated from the cytoplasm to nucleus upon exposure to growth factors, and oxidation of C106 described later is necessary for nuclear translocation of DJ-1 [61]. DJ-1 contains three cysteine residues, C46, C56, and C106. DJ-1 is also modified by sumoylation, S-nitrosylation, and phosphorylation.

特异性

PARK7 Rabbit Recombinant mAb detects endogenous level of PARK7.

背景

Protein deglycase DJ-1, also known as Parkinson disease protein 7 (PARK7) is a multifunctional protein that plays essential roles in tissues with higher order biological functions such as the testis and brain. DJ-1 has multiple functions: it works as an antioxidant, in transcriptional regulation, as a molecular chaperone and in protein degradation. DJ-1 is located in the cytoplasm, nucleus, and mitochondria in cells, and secreted DJ-1 has been observed in various cultured cells and tissues, including cancer cells and tissues. DJ-1 is translocated from the cytoplasm to nucleus upon exposure to growth factors, and oxidation of C106 described later is necessary for nuclear translocation of DJ-1 [61]. DJ-1 contains three cysteine residues, C46, C56, and C106. DJ-1 is also modified by sumoylation, S-nitrosylation, and phosphorylation.

使用信息

抗体应用

WB, IHC,ELISA,ELISA

稀释比例

WB	IHC
1:1000	1:50

反应性

Human Mouse Rat

MW (kDa)

20kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck

IHC

Validated by Selleck