PAX9 Rabbit Recombinant mAb Datasheet

生物描述

特异性	PAX9 Rabbit Recombinant mAb detects endogenous level of total PAX9.
背景	The paired-box (PAX) genes encode a family of nine well-characterized paired-box transcription factors, with important roles in development and disease. Subclassification of the PAX genes into subgroups (PAX1/PAX9, PAX2/PAX5/PAX8, PAX3/PAX7, PAX4/PAX6) on the basis of sequence correlates with expression patterns in developing embryonic tissues. The PAX genes are tightly regulated in both temporal and spatial expression patterns, and expression is observed primarily during fetal development, with the genes being switched off during latter phases of terminal differentiation of most structures. Although PAX genes are primarily expressed in the embryo, constitutive expression also promotes tissue hyperplasia. All Pax genes, with the exception of Pax4 and Pax9, produce alternative RNA transcripts. In mouse embryos, Pax9 is an early marker of tooth development, appearing in odontogenic mesenchyme before ectodermal thickening and prior to the expression of other tooth signaling genes. The expression of Pax9 also modulates the expression of crucial developmental regulatory genes, such as Msx1 and Bmp4, and antagonistic interactions between Fgf8 and Bmp2 or Bmp4 control the initiation of Pax9 expression in mandibular mesenchyme.

特异性

PAX9 Rabbit Recombinant mAb detects endogenous level of total PAX9.

背景

The paired-box (PAX) genes encode a family of nine well-characterized paired-box transcription factors, with important roles in development and disease. Subclassification of the PAX genes into subgroups (PAX1/PAX9, PAX2/PAX5/PAX8, PAX3/PAX7, PAX4/PAX6) on the basis of sequence correlates with expression patterns in developing embryonic tissues. The PAX genes are tightly regulated in both temporal and spatial expression patterns, and expression is observed primarily during fetal development, with the genes being switched off during latter phases of terminal differentiation of most structures. Although PAX genes are primarily expressed in the embryo, constitutive expression also promotes tissue hyperplasia. All Pax genes, with the exception of Pax4 and Pax9, produce alternative RNA transcripts. In mouse embryos, Pax9 is an early marker of tooth development, appearing in odontogenic mesenchyme before ectodermal thickening and prior to the expression of other tooth signaling genes. The expression of Pax9 also modulates the expression of crucial developmental regulatory genes, such as Msx1 and Bmp4, and antagonistic interactions between Fgf8 and Bmp2 or Bmp4 control the initiation of Pax9 expression in mandibular mesenchyme.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

36kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck