BMS-202

目录号：S7912 批次号：S791201

打印

化学数据

化学结构式 别名 PD-1/PD-L1 inhibitor 2 储存条件
(自收到货起)		 3年 / -20°C / 粉状
1年 / -80°C / 溶于溶剂
化学式

C25H29N3O3
分子量 419.52 CAS号 1675203-84-5
Solubility (25°C)* 体外 DMSO 83 mg/mL (197.84 mM)
Ethanol 83 mg/mL (197.84 mM)
Water Insoluble
体内
（现配现用）
均匀悬浊液
CMC-NA
≥5mg/ml 以 1 mL 工作液为例，取 5 mg该产品加到 1 ml CMC-NA 溶液中，混合均匀，即可得工作液浓度为 5 mg/ml的均匀悬浊液。
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述 BMS202是一种抑制PD-1/PD-L1相互作用的小分子化合物，IC50为18 nM。
靶点
PD-1/PD-L1 interaction
(Cell-free assay)
0.018 μM

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

BMS-202在文献中得到引用

Intracellular Localization of PD-L1 in Rab10-positive Open Tubular Endosome System of Cancer Cells [ Acta Histochemica et Cytochemica, February 27, 2026, 49-57] PubMed: 41810323
Prevalence of PD-L1 in Cervical Cancer Patients and the Potential for Combining an Immune Checkpoint Inhibitor With Lenvatinib [ Anticancer Research, February 15, 2024, 503-510] PubMed: 38307554
Molecular Targeted Agent and Immune Checkpoint Inhibitor Co-Loaded Thermosensitive Hydrogel for Synergistic Therapy of Rectal Cancer [ Frontiers in Pharmacology, April 16, 2021, 671611] PubMed: 33935796
Therapeutic potential of isochlorogenic acid A from Taraxacum officinale in improving immune response and enhancing the efficacy of PD-1/PD-L1 blockade in triple-negative breast cancer [ Front Immunol, 2025, 16:1529710] PubMed: 40109332
Itraconazole inhibits the Wnt/β-catenin signaling pathway to induce tumor-associated macrophages polarization to enhance the efficacy of immunotherapy in endometrial cancer [ Front Oncol, 2025, 15:1590095] PubMed: 40697374
Metabolic profiling of glioblastoma and identification of G0S2 as a metabolic target [ Front Oncol, 2025, 15:1572040] PubMed: 40519301
Impact of the PD-1/PD-L1 inhibitor SCL-1 on MDA-MB231 tumor growth in a humanized MHC-double knockout NOG mouse model [ Sci Rep, 2025, 15(1):26918] PubMed: 40707559
In Vivo Antitumor Activity of the PD-1/PD-L1 Inhibitor SCL-1 in Various Mouse Tumor Models [ In Vivo, 2025, 39(1):80-95] PubMed: 39740910
Uncovering the colorectal cancer immunotherapeutic potential: Evening primrose (Oenothera biennis) root extract and its active compound oenothein B targeting the PD-1/PD-L1 blockade [ Phytomedicine, 2024, 125:155370] PubMed: 38266440
Development and In Vivo Evaluation of Small-Molecule Ligands for Positron Emission Tomography of Immune Checkpoint Modulation Targeting Programmed Cell Death 1 Ligand 1 [ J Med Chem, 2024, 67(5):4036-4062] PubMed: 38442487

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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