PE Bcl-2 Antibody [100]

目录号：H2537

打印

生物描述

特异性
背景 Bcl-2是一种保守的抗凋亡蛋白，在正常免疫中起重要作用。它与其他Bcl-2家族成员形成同源或异源二聚体。该蛋白通过控制线粒体融合和裂变来调节细胞凋亡。Bcl-2的磷酸化已被证明可以增强其活性，以响应细胞外生长因子介导的信号。Bcl-2也受IRES、miR-15a、miR-16-1和RNA-BP nucleolin的调节。在滤泡淋巴瘤和一些弥漫性大B细胞淋巴瘤中经常观察到染色体18q21.3易位和Bcl-2的过表达。

使用信息

抗体应用 FCM, IHC 推荐用量 5 uL/million cells in 100 µL volume
反应性 Human
抗体类型 Mouse MW 26/22 KDa
储存液配方 Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA
储存条件
(自收到货起)		 Store at 4°C in the dark to avoid freeze-thaw cycles

Application Data

FCM

Validated by Selleck

  • Staining normal human peripheral blood mononuclear cells (HPBMCs) that were fixed/permeabilized with fixation/permeabilization buffer with PE Bcl-2 Antibody (Clone: 100) (Product Number: H2537) (green, red is unstained control). Analysis was performed on lymphocytes.