Pembrolizumab (anti-PD-1)

目录号：A2005         批次号: A200508

打印

Pembrolizumab (anti-PD-1)是一种有效的、高选择性的、人源IgG4-kappa单克隆抗体，同时也是抑制剂，靶向PD-1，具有潜在的免疫检查点抑制活性和抗肿瘤活性；MW：146.286 KD。

抗体信息

CAS号 1374853-91-4
配制 PBS buffer, pH 7.2
推荐同型对照 Human IgG4
来源 CHO cells
储存条件
(自收到货起)		 Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
纯度 99%
蛋白浓度 15.94mg/ml
内毒素 ＜1EU/mg

Pembrolizumab (anti-PD-1)在文献中得到引用

Regorafenib plus nivolumab in unresectable hepatocellular carcinoma: the phase 2 RENOBATE trial [ Nat Med, 2024, 10.1038/s41591-024-02824-y] PubMed: 38374347
The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable response to anti-PD-1 therapy via NLRP3 activation [ Cell Mol Immunol, 2024, 21(1):60-79] PubMed: 38062129
Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors [ Life Sci Alliance, 2024, 7(3)e202302368] PubMed: 38176728
[ BMC Cancer, 2024, ] PubMed: 38409035
Acquired resistance to CDK4/6 inhibition is associated with dysregulation of multiple pathways including cyclin D-CDK4/6-RB, EGFR/HER, AKT/mTOR and IFN [ Research Square, 2024, 10.21203/rs.3.rs-3782509/v1] PubMed: none
A20 promotes colorectal cancer immune evasion by upregulating STC1 expression to block "eat-me" signal [ Signal Transduct Target Ther, 2023, 8(1):312] PubMed: 37607946
Circulating extracellular vesicles are monitoring biomarkers of anti-PD1 response and enhancer of tumor progression and immunosuppression in metastatic melanoma [ J Exp Clin Cancer Res, 2023, 42(1):251] PubMed: 37759291
Complement receptor C5aR1 blockade reprograms tumor-associated macrophages and synergizes with anti-PD-1 therapy in gastric cancer [ Int J Cancer, 2023, 153(1):224-237] PubMed: 36799619
Complement receptor C5aR1 blockade reprograms tumor-associated macrophages and synergizes with anti-PD-1 therapy in gastric cancer [ Int J Cancer, 2023, 153(1):224-237] PubMed: 36799619
Expression of PD-1/PD-L1 axis in mediastinal lymph nodes and lung tissue of human and experimental lung fibrosis indicates a potential therapeutic target for idiopathic pulmonary fibrosis [ Respir Res, 2023, 24(1):279] PubMed: 37964265

禁止用于人体及治疗！