Pemigatinib

目录号：S0088 批次号：S008801

化学数据

	别名	INCB054828	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₂₄H₂₇F₂N₅O₄
	分子量	487.50	CAS号	1513857-77-6
Solubility (25°C)*	体外	DMSO	40 mg/mL (82.05 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Pemigatinib是一种口服活性的 FGFR 的选择性抑制剂，对于FGFR1、FGFR2、FGFR3和FGFR4的IC50分别为0.4 nM、0.5 nM、1.2 nM和30 nM。Pemigatinib（INCB054828）具有治疗胆管癌的潜力。

靶点

FGFR1 ^[1] (Cell-free assay)	FGFR2 ^[1] (Cell-free assay)	FGFR3 ^[1] (Cell-free assay)	FGFR4 ^[1] (Cell-free assay)
0.4 nM	0.5 nM	1.2 nM	30 nM

参考文献

Pemigatinib在文献中得到引用

Resistance to Selective FGFR Inhibitors in FGFR-Driven Urothelial Cancer [ Cancer Discov, 2023, 13(9):1998-2011]	PubMed: 37377403
Resistance to Selective FGFR Inhibitors in FGFR-Driven Urothelial Cancer [ Cancer Discov, 2023, 13(9):1998-2011]	PubMed: 37377403
Resistance to Selective FGFR Inhibitors in FGFR-Driven Urothelial Cancer [ Cancer Discov, 2023, 13(9):1998-2011]	PubMed: 37377403
A DNA/RNA heteroduplex oligonucleotide coupling asparagine depletion restricts FGFR2 fusion-driven intrahepatic cholangiocarcinoma [ Mol Ther Nucleic Acids, 2023, 34:102047]	PubMed: 37869260
Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury [ Cell Rep, 2023, 42(9):113121]	PubMed: 37715952
Coordinated inheritance of extrachromosomal DNA species in human cancer cells [ bioRxiv, 2023, 2023.07.18.549597]	PubMed: 37503111
Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury [ bioRxiv, 2023, 2023.05.05.539454]	PubMed: 37205445
EGFR Inhibition Potentiates FGFR Inhibitor Therapy and Overcomes Resistance in FGFR2 Fusion-Positive Cholangiocarcinoma [ Cancer Discov, 2022, 12(5):1378-1395]	PubMed: 35420673
Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation [ JCI Insight, 2022, 7(7)e154824]	PubMed: 35393953
Carcinoma of unknown primary: Molecular tumor board-based therapy [ CA Cancer J Clin, 2022, 2(6):510-523.]	PubMed: 36006378

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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