Nirogacestat (PF-03084014)

目录号：S8018 批次号：S801804

打印

化学数据

化学结构式 别名 PF-3084014 储存条件
(自收到货起)		 3年 / -20°C / 粉状
1年 / -80°C / 溶于溶剂
化学式

C27H41F2N5O
分子量 489.64 CAS号 1290543-63-3
Solubility (25°C)* 体外 DMSO 98 mg/mL (200.14 mM)
Ethanol 98 mg/mL (200.14 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 Nirogacestat (PF-03084014, PF-3084014) 是一种选择性gamma-secretase抑制剂，在无细胞试验中IC50为6.2 nM。Nirogacestat (PF-03084014, PF-3084014) 可诱导凋亡。Phase 2。
靶点
gamma-secretase [1]
(cell-free assay)
6.2 nM

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

客户使用selleck产品的实验数据

数据来源于[Data independently produced by , , Cell Prolif, 2018, 51(3):e12424]

数据来源于[Data independently produced by , , Cell Prolif, 2017, doi: 10.1111/cpr.12424]

Nirogacestat (PF-03084014)在文献中得到引用

Activation of the γ-secretase/NICD-PXR/Notch pathway induces Taxol resistance in triple-negative breast cancer [ Biochem Pharmacol, 2024, 230(Pt 2):116577] PubMed: 39427919
Multiomic analyses reveal new targets of polycomb repressor complex 2 in Schwann lineage cells and malignant peripheral nerve sheath tumors [ Neurooncol Adv, 2024, 6(1):vdae188] PubMed: 39620202
Inhibition of Notch Signaling Enhances Antitumor Activity of Histone Deacetylase Inhibitor LAQ824 [ Int J Mol Sci, 2023, 24(17)13660] PubMed: 37686467
Inhibition of Notch Signaling Enhances Antitumor Activity of Histone Deacetylase Inhibitor LAQ824 [ Int J Mol Sci, 2023, 24(17)13660] PubMed: 37686467
Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia [ Cancers (Basel), 2023, 15(6)1883] PubMed: 36980769
In vitro effects of gamma-secretase inhibition in HPV-positive and HPV-negative head and neck squamous cell carcinoma [ Invest New Drugs, 2023, 41(2):193-201] PubMed: 36809443
In vitro effects of gamma-secretase inhibition in HPV-positive and HPV-negative head and neck squamous cell carcinoma [ Invest New Drugs, 2023, 41(2):193-201] PubMed: 36809443
Pharmacological conversion of gut epithelial cells into insulin-producing cells lowers glycemia in diabetic animals [ J Clin Invest, 2022, 132(24)e162720] PubMed: 36282594
DT7 peptide-modified lecithin nanoparticles co-loaded with γ-secretase inhibitor and dexamethasone efficiently inhibit T-cell acute lymphoblastic leukemia and reduce gastrointestinal toxicity [ Cancer Lett, 2022, 533:215608] PubMed: 35240234
BRAFV600E;K601Q metastatic melanoma patient-derived organoids and docking analysis to predict the response to targeted therapy [ Pharmacol Res, 2022, 182:106323] PubMed: 35752358

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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