PMA (Phorbol 12-myristate 13-acetate)

目录号：S7791 批次号：S779105

化学数据

	别名	12-O-Tetradecanoylphorbol-13-acetate,TPA, Phorbol myristate acetate	储存条件 (自收到货起)	3年 -20°C(避光) 粉状
	化学式	C₃₆H₅₆O₈
	分子量	616.83	CAS号	16561-29-8
Solubility (25°C)*	体外	DMSO	100 mg/mL (162.11 mM)
		Ethanol	100 mg/mL (162.11 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述	PMA (Phorbol 12-myristate 13-acetate)是一种有效的PKC激活剂，在纳摩尔浓度范围内具有活性作用。Phorbol 12-myristate 13-acetate (PMA)可诱导sphingosine-1-phosphate (S1P)。PMA对皮肤和粘膜具有强激性，在使用PMA时需要特别防护,戴好手套和面罩,避免任何途径直接接触。

参考文献

[1] Wen HC, et al. Sci Rep. 2018 Nov 2;8(1):16247.

PMA (Phorbol 12-myristate 13-acetate)在文献中得到引用

Neutrophil extracellular traps license macrophage production of chemokines to facilitate CD8+ T cell infiltration in obstruction-induced renal fibrosis [ Protein Cell, 2025, pwaf020]	PubMed: 39998389
Pharmacological Modulation of the Unfolded Protein Response as a Therapeutic Approach in Cutaneous T-Cell Lymphoma [ Biomolecules, 2025, 15(1)76]	PubMed: 39858470
Using major histocompatibility complex (MHC) II expression to predict antitumor response to CD4 + lymphocyte depletion [ Sci Rep, 2025, 15(1):5469]	PubMed: 39953106
Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8+ T cell exhaustion and anti-PD-1 resistance [ Cell Rep Med, 2024, 5(8):101686]	PubMed: 39168104
GPR65 sensing tumor-derived lactate induces HMGB1 release from TAM via the cAMP/PKA/CREB pathway to promote glioma progression [ J Exp Clin Cancer Res, 2024, 43(1):105]	PubMed: 38576043
PKCα Induced the Generation of Extracellular Vesicles in Activated Platelets to Promote Breast Cancer Metastasis [ Int J Biol Sci, 2024, 20(10):3956-3971]	PubMed: 39113702
Bile acid derivatives from gut microbiota promote GBPs-mediated activation of caspase-4/11 by LPS through lncRNA57RIK [ Int J Biol Sci, 2024, 20(15):5831-5849]	PubMed: 39664579
LINC00330/CCL2 axis-mediated ESCC TAM reprogramming affects tumor progression [ Cell Mol Biol Lett, 2024, 29(1):77]	PubMed: 38769475
CircMLH3 induces mononuclear macrophage pyroptosis in sepsis by sponging miR-590-3p to regulate TAK1 expression [ Int J Biol Macromol, 2024, 263(Pt 1):130179]	PubMed: 38378118
UBR5 metabolically reprograms nasopharyngeal carcinoma cells to promote glycolysis and M2 polarization via SPLUNC1 signaling [ NPJ Precis Oncol, 2024, 8(1):252]	PubMed: 39501021

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

退换货政策

Selleck提供宽松的退换货承诺，努力为您营造最优的购物体验。每个订单Selleck只提供一次退换货服务，为了确保您的权益，请您仔细阅读以下内容：

1. 请在返还样品之前事先与我们取得联系，以确保产品是直接向我们或者当地代理商购买的；

2. 自收到货物起七天内，如因运输过程有问题或其他任何问题，您可以提出退换货要求；自收到货物起365天内，如因产品质量有问题，您可以提出退换货要求。

3. 请使用我们的快递账号进行退换货，您无需为此承担任何费用。

4. 如您已收到由Selleck开具的发票，则办理退货或订单金额发生变更的换货时，请将发票随商品一同返还给Selleck。请您妥善保管发票，如发票丢失，将无法办理退换货手续。