Datasheet

生物描述

特异性	Phospho-Stat5 (Y694) Rabbit Recombinant mAb detects endogenous levels of phosphorylated Stat5 (Y694).
背景	Signal transducer and activator of transcription 5 (STAT5) is a prominent member of the STAT family, which exists in two highly homologous isoforms, STAT5A and STAT5B. STAT5 phosphorylation at tyrosine 694 (Y694) is essential for cell survival, proliferation, angiogenesis and metastasis in certain cancers of both hematopoietic and non-hematopoietic origin. Phosphorylation at Y694 is required for the sumoylation of STAT5A and is obligatory for Stat5 activation. Stat5 is localized in the cytoplasm and upon phosphorylation at Y694 is translocated to the nucleus.

特异性

Phospho-Stat5 (Y694) Rabbit Recombinant mAb detects endogenous levels of phosphorylated Stat5 (Y694).

背景

Signal transducer and activator of transcription 5 (STAT5) is a prominent member of the STAT family, which exists in two highly homologous isoforms, STAT5A and STAT5B. STAT5 phosphorylation at tyrosine 694 (Y694) is essential for cell survival, proliferation, angiogenesis and metastasis in certain cancers of both hematopoietic and non-hematopoietic origin. Phosphorylation at Y694 is required for the sumoylation of STAT5A and is obligatory for Stat5 activation. Stat5 is localized in the cytoplasm and upon phosphorylation at Y694 is translocated to the nucleus.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse

MW (kDa)

90kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Zhuo Ren, et al. Cell Death Dis. 2016, 7(12): e2560.

Application Data

WB

Validated by Selleck