Datasheet

生物描述

特异性	Phospho-Tau (S396) Rabbit Recombinant mAb detects endogenous levels of phosphorylated Tau (S396).
背景	Tau is a microtubule-associated protein that is important for microtubule stabilization and axon elongation. Tau can be phosphorylated at multiple epitopes, and there is some evidence to suggest that phosphorylation at particular sites can confer specific attributes to the tau protein. Tau is robustly phosphorylated at both the S396 and S404 residues following the activation of NMDARs. Phosphorylation at S396 contributes to reduced tau-microtubule binding, and is also correlated with C-terminal tau cleavage and distinct conformational changes. Modification of phosphorylation in tau-T231 or p-tau S396 may play a role in formation of NFT in the Alzheimer's disease (AD) brain, whereas especially tau-S396-404 seems to be one of the earliest molecular targets in AD.

特异性

Phospho-Tau (S396) Rabbit Recombinant mAb detects endogenous levels of phosphorylated Tau (S396).

背景

Tau is a microtubule-associated protein that is important for microtubule stabilization and axon elongation. Tau can be phosphorylated at multiple epitopes, and there is some evidence to suggest that phosphorylation at particular sites can confer specific attributes to the tau protein. Tau is robustly phosphorylated at both the S396 and S404 residues following the activation of NMDARs. Phosphorylation at S396 contributes to reduced tau-microtubule binding, and is also correlated with C-terminal tau cleavage and distinct conformational changes. Modification of phosphorylation in tau-T231 or p-tau S396 may play a role in formation of NFT in the Alzheimer's disease (AD) brain, whereas especially tau-S396-404 seems to be one of the earliest molecular targets in AD.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

50-80kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck