PI 3 Kinase p110 delta Rabbit Recombinant mAb Datasheet

生物描述

特异性	PI 3 Kinase p110 delta Rabbit Recombinant mAb detects endogenous level of total PI3 Kinase p110 delt.
背景	Members of phosphatidylinositol-3-OH kinase (PI(3)K) class I generate the second messenger phosphatidylinositol-(3,4,5)-trisphosphate (PtdIns(3,4,5)P3), which is important for a broad range of cell responses, including proliferation, cytoskeletal dynamics and vesicular traffickin. Mammals have eight PI(3)K isoforms that are divided into three classes. The class IA PI(3)K catalytic subunits (p110α, p110β and p110δ) are found in complex with the Src-homology 2 domain-containing regulatory subunit p85 and are acutely activated by tyrosine kinases or G protein–coupled receptors. p110δ is the main class I PI(3)K isoform recruited to the activated TLR4 complex, where it converted PtdIns(4,5)P2 to PtdIns(3,4,5)P3 after activation by LPS. While p110α and p110β are ubiquitously expressed, p110γ and p110δ are predominantly found in haematopoietic cells.

特异性

PI 3 Kinase p110 delta Rabbit Recombinant mAb detects endogenous level of total PI3 Kinase p110 delt.

背景

Members of phosphatidylinositol-3-OH kinase (PI(3)K) class I generate the second messenger phosphatidylinositol-(3,4,5)-trisphosphate (PtdIns(3,4,5)P3), which is important for a broad range of cell responses, including proliferation, cytoskeletal dynamics and vesicular traffickin. Mammals have eight PI(3)K isoforms that are divided into three classes. The class IA PI(3)K catalytic subunits (p110α, p110β and p110δ) are found in complex with the Src-homology 2 domain-containing regulatory subunit p85 and are acutely activated by tyrosine kinases or G protein–coupled receptors. p110δ is the main class I PI(3)K isoform recruited to the activated TLR4 complex, where it converted PtdIns(4,5)P2 to PtdIns(3,4,5)P3 after activation by LPS. While p110α and p110β are ubiquitously expressed, p110γ and p110δ are predominantly found in haematopoietic cells.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

119kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck