PIM1 Rabbit Recombinant mAb Datasheet

生物描述

特异性	PIM1 Rabbit Recombinant mAb detects endogenous level of total PIM1.
背景	PIM kinases are a family of serine/threonine kinases involved in cell survival and proliferation. The kinase family is composed of three members PIM1, PIM2 and PIM3, which are highly evolutionarily conserved in nearly all multicellular organisms. All three kinases are expressed in hematopoietic, neuronal, cardiomyocyte, endothelial, epithelial cell lineages and in embryonic stem cells. PIM1 was originally identified as a common site of Moloney murine leukemia proviral insertion. PIM1 cooperates with c-MYC and n-MYC during lymphomagenesis, also collaborates with BCL2, GFI1 and E2A-PBX1 to promote lymphomagenesis. It mediates cell cycle regulators via phosphorylation such as cyclin-dependent kinase inhibitor 1 (CDK1A/B) and cell division cycle 25A (CDC25A/C).

特异性

PIM1 Rabbit Recombinant mAb detects endogenous level of total PIM1.

背景

PIM kinases are a family of serine/threonine kinases involved in cell survival and proliferation. The kinase family is composed of three members PIM1, PIM2 and PIM3, which are highly evolutionarily conserved in nearly all multicellular organisms. All three kinases are expressed in hematopoietic, neuronal, cardiomyocyte, endothelial, epithelial cell lineages and in embryonic stem cells. PIM1 was originally identified as a common site of Moloney murine leukemia proviral insertion. PIM1 cooperates with c-MYC and n-MYC during lymphomagenesis, also collaborates with BCL2, GFI1 and E2A-PBX1 to promote lymphomagenesis. It mediates cell cycle regulators via phosphorylation such as cyclin-dependent kinase inhibitor 1 (CDK1A/B) and cell division cycle 25A (CDC25A/C).

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse

MW (kDa)

32kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Kumar Saurabh, et al. Oncotarget. 2014, 5(18): 8503-8514.

Application Data

WB

Validated by Selleck