Datasheet

生物描述

特异性	PKA2 beta Rabbit Recombinant mAb detects endogenous levels of total PKA2 beta.
背景	Protein kinase A (PKA) is the main target of cAMP with four regulatory subunits showing tissue-specific expression and function: among the subunits, PRKAR2B is a cAMP-dependent, regulatory, type II alpha protein kinase regulating protein transport from endosomes to the Golgi apparatus and the endoplasmic reticulum in apoptotic pathways. It is mainly expressed in the brain, adipose tissue and endocrine organs. The PKA signaling pathway is differentially activated by the expression of regulatory subunits 1 (R1) and 2 (R2), whose levels change during development, differentiation, and neoplastic transformation. PRKAR2B could interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells.

特异性

PKA2 beta Rabbit Recombinant mAb detects endogenous levels of total PKA2 beta.

背景

Protein kinase A (PKA) is the main target of cAMP with four regulatory subunits showing tissue-specific expression and function: among the subunits, PRKAR2B is a cAMP-dependent, regulatory, type II alpha protein kinase regulating protein transport from endosomes to the Golgi apparatus and the endoplasmic reticulum in apoptotic pathways. It is mainly expressed in the brain, adipose tissue and endocrine organs. The PKA signaling pathway is differentially activated by the expression of regulatory subunits 1 (R1) and 2 (R2), whose levels change during development, differentiation, and neoplastic transformation. PRKAR2B could interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

46kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck