PKC alpha Rabbit Recombinant mAb Datasheet

生物描述

特异性	PKC alpha Rabbit Recombinant mAb detects endogenous level of PKC alpha.
背景	Protein kinase C α is a serine/threonine kinase and a member of the conventional (classical) PKCs (cPKCs). This ubiquitously expressed PKC isotype is activated in response to many different kinds of stimuli and translocates from cytosol to the specialized cellular compartments (nucleus, focal adhesion, caveolae, etc.) where it is presumed to work. Therefore, PKCα has been implicated in a variety of cellular functions including proliferation, apoptosis, differentiation, motility, and inflammation. Upon stimulation, PKCα translocates from cytosol to a so-called particulate fraction and phosphorylates a variety of substrates depending on the types of stimuli and cells.

特异性

PKC alpha Rabbit Recombinant mAb detects endogenous level of PKC alpha.

背景

Protein kinase C α is a serine/threonine kinase and a member of the conventional (classical) PKCs (cPKCs). This ubiquitously expressed PKC isotype is activated in response to many different kinds of stimuli and translocates from cytosol to the specialized cellular compartments (nucleus, focal adhesion, caveolae, etc.) where it is presumed to work. Therefore, PKCα has been implicated in a variety of cellular functions including proliferation, apoptosis, differentiation, motility, and inflammation. Upon stimulation, PKCα translocates from cytosol to a so-called particulate fraction and phosphorylates a variety of substrates depending on the types of stimuli and cells.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

75kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Nakashima S. J Biochem. 2002, 132(5):669-75.

Application Data

WB

Validated by Selleck