PMA (Phorbol 12-myristate 13-acetate)

目录号：S7791 批次号：S779105

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化学数据

化学结构式 别名 12-O-Tetradecanoylphorbol-13-acetate,TPA, Phorbol myristate acetate 储存条件
(自收到货起)		 3年 -20°C(避光) 粉状
化学式

C36H56O8
分子量 616.83 CAS号 16561-29-8
Solubility (25°C)* 体外 DMSO 100 mg/mL (162.11 mM)
Ethanol 100 mg/mL (162.11 mM)
Water Insoluble
体内
（现配现用）
均匀悬浊液
CMC-NA
≥5mg/ml 以 1 mL 工作液为例，取 5 mg该产品加到 1 ml CMC-NA 溶液中，混合均匀，即可得工作液浓度为 5 mg/ml的均匀悬浊液。
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述 PMA (Phorbol 12-myristate 13-acetate)是一种有效的PKC激活剂，在纳摩尔浓度范围内具有活性作用。Phorbol 12-myristate 13-acetate (PMA)可诱导sphingosine-1-phosphate (S1P)。PMA对皮肤和粘膜具有强激性，在使用PMA时需要特别防护,戴好手套和面罩,避免任何途径直接接触。

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

PMA (Phorbol 12-myristate 13-acetate)在文献中得到引用

Neutrophil extracellular traps license macrophage production of chemokines to facilitate CD8+ T cell infiltration in obstruction-induced renal fibrosis [ Protein Cell, 2025, pwaf020] PubMed: 39998389
Granzyme B activated near-infrared-II ratiometric fluorescent nanoprobe for early detection of tumor response to immunotherapy [ Nat Commun, 2025, 16(1):8054] PubMed: 40877261
Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-hyperactivated intrahepatic cholangiocarcinoma [ Cancer Commun (Lond), 2025, 10.1002/cac2.70036] PubMed: 40443016
Unveiling the mechanisms of CEBPD-orchestrated TAM polarization through RGS2/PAR2 pathway and its impact on ICB efficacy in clear cell renal cell carcinoma [ J Immunother Cancer, 2025, 13(7)e010898] PubMed: 40659446
Dynamic phosphorylation of Fascin-1 orchestrates microglial phagocytosis and neurological recovery after spinal cord injury [ J Neuroinflammation, 2025, 22(1):121] PubMed: 40281563
The Hippo pathway kinase MST1 mediates a feedback loop to maintain NLRP3 inflammasome homeostasis [ Cell Rep, 2025, 44(8):116076] PubMed: 40716062
Rottlerin inhibits PKCδ to attenuate pulmonary fibrosis by suppressing NLRC4/ASC-mediated pyroptosis [ Phytomedicine, 2025, 146:157154] PubMed: 40819638
Targeting CCR5 with miltefosine as a therapeutic strategy for thrombocytopenia [ iScience, 2025, 28(5):112379] PubMed: 40292315
Ursolic acid ameliorates cerebral ischemia-reperfusion injury by inhibiting NF-κB/NLRP3-mediated microglia pyroptosis and neuroinflammation [ Front Pharmacol, 2025, 16:1622131] PubMed: 40717974
Cooperative targeting of NF-κB enhances ferroptosis-driven HCC therapy with Alisertib and Donafenib [ Front Cell Dev Biol, 2025, 13:1637767] PubMed: 40881350

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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