Prexasertib (LY2606368)

目录号：S6385 批次号：S638501

化学数据

	别名	ACR 368	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₁₈H₁₉N₇O₂
	分子量	365.39	CAS号	1234015-52-1
Solubility (25°C)*	体外	DMSO	3 mg/mL (8.21 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Prexasertib (LY2606368, ACR 368) 是 Chk1 和 Chk2 的选择性 ATP 竞争抑制剂，在无细胞试验中的 IC50 分别为 1 nM 和 8 nM。Prexasertib 在无细胞试验中也抑制 RSK1，IC50 为 9 nM。

靶点

Chk1 ^[1] (in cell-free assay)	Chk2 ^[1] (in cell-free assay)	RSK1 ^[1] (in cell-free assay)
1 nM	8 nM	9 nM

参考文献

[1] David Hong, et al. J Clin Oncol. 2016 May 20;34(15):1764-71.

Prexasertib (LY2606368)在文献中得到引用

Comprehensive multi-omics analysis reveals WEE1 as a synergistic lethal target with hyperthermia through CDK1 super-activation [ Nat Commun, 2024, 15(1):2089]	PubMed: 38453961
Glutamine metabolism prognostic index predicts tumour microenvironment characteristics and therapeutic efficacy in ovarian cancer [ J Cell Mol Med, 2024, 28(7):e18198]	PubMed: 38506093
Actionable loss of SLF2 drives B-cell lymphomagenesis and impairs the DNA damage response [ EMBO Mol Med, 2023, e16431.]	PubMed: 37485814
Combination drug screen targeting glioblastoma core vulnerabilities reveals pharmacological synergisms [ EBioMedicine, 2023, 95:104752]	PubMed: 37572644
Phosphatases maintain low catalytic activity of SGK1: DNA damage resets the balance in favor of phosphorylation [ J Biol Chem, 2023, S0021-9258(23)01969-5]	PubMed: 37343701
CHEK2 signaling is the key regulator of oocyte survival after chemotherapy [ Sci Adv, 2023, 9(42):eadg0898]	PubMed: 37862420
Activator Protein-1 (AP-1) Signaling Inhibits the Growth of Ewing Sarcoma Cells in Response to DNA Replication Stress [ Cancer Res Commun, 2023, 3(8):1580-1593]	PubMed: 37599787
Clinically relevant CHK1 inhibitors abrogate wild-type and Y537S mutant ERα expression and proliferation in luminal primary and metastatic breast cancer cells [ J Exp Clin Cancer Res, 2022, 41(1):141]	PubMed: 35418303
Oncogenic RAS sensitizes cells to drug-induced replication stress via transcriptional silencing of P53 [ Oncogene, 2022, 41(19):2719-2733]	PubMed: 35393546
Salt-Inducible Kinase 1 is a potential therapeutic target in Desmoplastic Small Round Cell Tumor [ Oncogenesis, 2022, 11(1):18]	PubMed: 35443736

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

退换货政策

Selleck提供宽松的退换货承诺，努力为您营造最优的购物体验。每个订单Selleck只提供一次退换货服务，为了确保您的权益，请您仔细阅读以下内容：

1. 请在返还样品之前事先与我们取得联系，以确保产品是直接向我们或者当地代理商购买的；

2. 自收到货物起七天内，如因运输过程有问题或其他任何问题，您可以提出退换货要求；自收到货物起365天内，如因产品质量有问题，您可以提出退换货要求。

3. 请使用我们的快递账号进行退换货，您无需为此承担任何费用。

4. 如您已收到由Selleck开具的发票，则办理退货或订单金额发生变更的换货时，请将发票随商品一同返还给Selleck。请您妥善保管发票，如发票丢失，将无法办理退换货手续。