Pro Caspase 7 Rabbit Recombinant mAb

目录号：A5667

生物描述

特异性	Pro Caspase 7 Rabbit Recombinant mAb detects endogenous level of total Pro Caspase 7.
背景	Intrinsic and extrinsic apoptotic pathways converge to activate common downstream executioner caspases (caspase-3, -6, and -7), resulting in cell death. Procaspase-7 is generated as a protein of 303 amino acids (Figure 2A) that resides in the cytosol as a pre-assembled homodimer and is cleaved by caspase 3, caspase 10, and caspase 9. Thus, caspase-7 is activated upon cell death stimuli and induces apoptosis.

特异性

Pro Caspase 7 Rabbit Recombinant mAb detects endogenous level of total Pro Caspase 7.

背景

Intrinsic and extrinsic apoptotic pathways converge to activate common downstream executioner caspases (caspase-3, -6, and -7), resulting in cell death. Procaspase-7 is generated as a protein of 303 amino acids (Figure 2A) that resides in the cytosol as a pre-assembled homodimer and is cleaved by caspase 3, caspase 10, and caspase 9. Thus, caspase-7 is activated upon cell death stimuli and induces apoptosis.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

1:1000

反应性

Human

MW (kDa)

34kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Gafni J, et al. J Biol Chem. 2009, 284(37):25441-9.
[2] Lamkanfi M, et al. Int J Biochem Cell Biol. 2010, 42(1):21-4.
[3] Patel V, et al. Blood. 2015, 125(7):1126-36.

Application Data

Validated by Selleck