PRP19 Rabbit Recombinant mAb

生物描述

特异性

PRP19 Rabbit Recombinant mAb detects endogenous level of total PRP19.

背景

PRP19 is a ubiquitin ligase involved in pre-mRNA splicing and the DNA damage response (DDR). The conserved Prp19 complex (Prp19C) -- also known as NineTeen Complex (NTC) — functions in several processes of paramount importance for cellular homeostasis. Prp19 contains a U-box domain at its N-terminus, which is structurally related to the RING finger motif found in certain E3 ubiquitin ligases, and exhibits E3 ligase activity in vitro and in vivo. Prp19 functions in protein degradation and may transport its substrates to the proteasome by binding to proteasomal subunits. Prp19 is not only present in the nucleus, but also in the cytoplasm, where it is associated with lipid droplets and functions in lipid droplet biogenesis.

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	55kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Chanarat S, et al. Biochim Biophys Acta. 2013, 1833(10):2126-34.

Application Data

WB

IF