PTP1B Rabbit Recombinant mAb Datasheet

生物描述

特异性	PTP1B Rabbit Recombinant mAb detects endogenous level of total PTP1B.
背景	PTP1B is a ubiquitously expressed tyrosine phosphatase with well-characterized functions in metabolic signaling pathways. PTP1B localized at the cytoplasmic face of ER and can also be released from the ER and relocated to the cytoplasm by a calpain-mediated proteolytic cleavage. PTP1B is an important negative regulator of the insulin receptor and various growth factor receptors, such as epidermal growth factor, platelet-derived growth factor, and insulin-like growth factor-I receptors. PTP1B also limits Toll-like receptor signaling in macrophages and inhibits leptin receptor signaling by dephosphorylating the receptor-associated kinase JAK2. Other nonreceptor tyrosine kinases, including c-Src, Bcr-Abl, and TYK2, as well as the transcription factor STAT6, are also substrates of PTP1B. Downregulation of PTP1B ameliorates ER stress in obesity and diabetes models. PTP1B potentiates IRE-1-mediated ER stress response and its expression is regulated by ATF6. It mediates the toxic consequences of neuronal ER stress.

特异性

PTP1B Rabbit Recombinant mAb detects endogenous level of total PTP1B.

背景

PTP1B is a ubiquitously expressed tyrosine phosphatase with well-characterized functions in metabolic signaling pathways. PTP1B localized at the cytoplasmic face of ER and can also be released from the ER and relocated to the cytoplasm by a calpain-mediated proteolytic cleavage. PTP1B is an important negative regulator of the insulin receptor and various growth factor receptors, such as epidermal growth factor, platelet-derived growth factor, and insulin-like growth factor-I receptors. PTP1B also limits Toll-like receptor signaling in macrophages and inhibits leptin receptor signaling by dephosphorylating the receptor-associated kinase JAK2. Other nonreceptor tyrosine kinases, including c-Src, Bcr-Abl, and TYK2, as well as the transcription factor STAT6, are also substrates of PTP1B. Downregulation of PTP1B ameliorates ER stress in obesity and diabetes models. PTP1B potentiates IRE-1-mediated ER stress response and its expression is regulated by ATF6. It mediates the toxic consequences of neuronal ER stress.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human

MW (kDa)

50kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck