Puromycin

目录号:E4996

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化学数据

化学结构式 别名 CL13900, Puromycine 储存条件
(自收到货起)
3年 / -20°C / 粉状
1年 / -80°C / 溶于溶剂
化学式

C22H29N7O5

分子量 471.51 CAS号 53-79-2
Solubility (25°C)* 体外
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

生物活性

产品描述 Puromycin (CL13900, Puromycine) 是一种抗生素,是氨酰-tRNA 3' 端的类似物,也是模拟酪氨酰-tRNA 的蛋白质合成抑制剂,可导致翻译过早终止。它通过标记和释放核糖体延长的多肽链来阻止翻译,并已广泛应用于分子生物学研究。

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

Puromycin在文献中得到引用

Alterations in PD-L1 succinylation shape anti-tumor immune responses in melanoma [ Nat Genet, 2025, 57(3):680-693] PubMed: 40069506
Microprotein PLUM encoded by Lin28b uORF is a cytoplasmic determinant of pluripotency and embryonic development [ Nat Commun, 2025, 16(1):10324] PubMed: 41298451
CD137L promotes immune surveillance in melanoma via HLTF regulation [ Nat Commun, 2025, 16(1):8478] PubMed: 41006211
BRD8 Guards the Pluripotent State by Sensing and Maintaining Histone Acetylation [ Adv Sci (Weinh), 2025, 12(5):e2409160] PubMed: 39656858
Ints7 deficiency activates DNA damage response to elicit resurgence of endogenous retrovirus MERVL and anastasis of embryonic stem cells [ Nucleic Acids Res, 2025, 53(15)gkaf797] PubMed: 40842237
ELTD1 inhibits differentiation of hemogenic endothelium progenitors from human embryonic stem cells through the HPIP-Wnt pathway [ Exp Mol Med, 2025, 57(6):1216-1231] PubMed: 40456828
A novel pathway for stemness propagation and chemoresistance in non-small cell lung cancer via phosphorylated PKM2-loaded small extracellular vesicles [ Theranostics, 2025, 15(8):3439-3461] PubMed: 40093893
The de novo DNA methyltransferase 3B is a novel epigenetic regulator of MYC in multiple myeloma, representing a promising therapeutic target to counter relapse [ J Exp Clin Cancer Res, 2025, 44(1):125] PubMed: 40241199
Keratin 6A promotes skin inflammation through JAK1-STAT3 activation in keratinocytes [ J Biomed Sci, 2025, 32(1):47] PubMed: 40346694
Unveiling the mechanisms of CEBPD-orchestrated TAM polarization through RGS2/PAR2 pathway and its impact on ICB efficacy in clear cell renal cell carcinoma [ J Immunother Cancer, 2025, 13(7)e010898] PubMed: 40659446

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。

如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!

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