Pyrvinium pamoate

目录号：S5816 批次号：S581602

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化学数据

化学结构式 别名 Pyrvinium embonate 储存条件
(自收到货起)		 3年 -20°C 粉状
化学式

C75H70N6O6
分子量 1151.39 CAS号 3546-41-6
Solubility (25°C)* 体外 DMSO 24 mg/mL (20.84 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 Pyrvinium pamoate(Pyrvinium embonate)是一种驱虫剂，对蛲虫有效。

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

Pyrvinium pamoate在文献中得到引用

Repurposing FDA-Approved Drugs for Temozolomide-Resistant IDH1 Mutant Glioma Using High-Throughput Miniaturized Screening on Droplet Microarray Chip [ Adv Healthc Mater, 2023, e2300591.] PubMed: 37162029
Synergistic effect of pyrvinium pamoate and posaconazole against Cryptococcus neoformans in vitro and in vivo [ Front Cell Infect Microbiol, 2022, 12:1074903] PubMed: 36569209
The FDA-Approved Drug Pyrvinium Selectively Targets ER+ Breast Cancer Cells with High INPP4B Expression [ Cancers (Basel), 2022, 15(1)135] PubMed: 36612130
The Casein kinase 1α agonist pyrvinium attenuates Wnt-mediated CK1α degradation via interaction with the E3 ubiquitin ligase component Cereblon [ J Biol Chem, 2022, 298(8):102227] PubMed: 35780831
β-catenin inhibitors ICG-001 and pyrvinium sensitize bortezomib-resistant multiple myeloma cells to bortezomib [ Oncol Lett, 2022, 24(1):205] PubMed: 35720475
Inhibiting Wnt/beta-catenin in CTNNB1-mutated endometrial cancer [ Mol Carcinog, 2021, 10.1002/mc.23308] PubMed: 34038589
Pyrvinium pamoate inhibits cell proliferation through ROS-mediated AKT-dependent signaling pathway in colorectal cancer [ Med Oncol, 2021, 38(2):21] PubMed: 33554313
In vitro and in vivo Study of Antifungal Effect of Pyrvinium Pamoate Alone and in Combination With Azoles Against Exophiala dermatitidis [ Front Cell Infect Microbiol, 2020, 10:576975] PubMed: 33194816
Synergistic Effect of Pyrvinium Pamoate and Azoles Against Aspergillus fumigatus in vitro and in vivo [ Front Microbiol, 2020, 11:579362] PubMed: 33224118
Reversal of Infected Host Gene Expression Identifies Repurposed Drug Candidates for COVID-19 [ bioRxiv, 2020, 2020/9/20.4.7.30734] PubMed: 32511305

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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