Datasheet

生物描述

特异性	RAB11A Rabbit Recombinant mAb detects endogenous levels of total RAB11A.
背景	The Rab11 subfamily consists of three isoforms--Rab11a, Rab11b, and Rab25. Rab11a and Rab11b are ubiquitously expressed, whereas Rab25 expression is restricted to epithelial cells. Rab11 proteins regulate the slow recycling of the transferrin receptor to the plasma membrane and Rab11 is highly concentrated in the perinuclear endocytic recycling compartment (ERC). Like all GTPases of the Ras family, Rab11 functions as a molecular switch. Rabs associate with membranes in the guanosine diphosphate (GDP)-bound form and switch to a GTP-bound conformation in a reaction catalyzed by a GEF. Rab11a is an important regulator of TLR4 trafficking and regulates transport of TLR4 to endosomes. It is a well-defined marker of apical recycling endosomes.

特异性

RAB11A Rabbit Recombinant mAb detects endogenous levels of total RAB11A.

背景

The Rab11 subfamily consists of three isoforms--Rab11a, Rab11b, and Rab25. Rab11a and Rab11b are ubiquitously expressed, whereas Rab25 expression is restricted to epithelial cells. Rab11 proteins regulate the slow recycling of the transferrin receptor to the plasma membrane and Rab11 is highly concentrated in the perinuclear endocytic recycling compartment (ERC). Like all GTPases of the Ras family, Rab11 functions as a molecular switch. Rabs associate with membranes in the guanosine diphosphate (GDP)-bound form and switch to a GTP-bound conformation in a reaction catalyzed by a GEF. Rab11a is an important regulator of TLR4 trafficking and regulates transport of TLR4 to endosomes. It is a well-defined marker of apical recycling endosomes.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

24kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Husebye H, et al. Immunity. 2010, 33(4):583-96.

Application Data

WB

Validated by Selleck