Rac1/2/3 Rabbit Recombinant mAb detects endogenous levels of total Rac1/2/3.

Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. There proteins are implicated in the control of cytoskeletal events and coordinate diverse cellular functions, including cell polarity, vesicular trafficking, the cell cycle and transcriptomal dynamics. Three different Rac isoforms have been described in humans. Rac1, Rac2, and Rac3 are highly related GTPases belonging to the Rho subfamily of Ras proteins. Rac2 is the predominant isoform in neutrophils and has been shown to be essential for NADPH oxidase activity. In resting neutrophils, Rac2 is complexed with Rho GDP dissociation inhibitor (RhoGDI) in the cytosol forming a heterodimer. Among these proteins, Rac1 is ubiquitously expressed, Rac2 is expressed only in hematopoietic cells, and Rac3 is expressed primarily in the brain.