Datasheet

生物描述

特异性	RAIDD Rabbit Recombinant mAb detects endogenous levels of total RAIDD.
背景	Death domain-containing protein CRADD, also known as RAIDD (RIP-associated ICH-1/CED-3- homologous protein with a death domain), induces cell apoptosis. RAIDD negatively regulates NFκB-dependent cytokine and chemokine expression in T cells by targeting the NH2-terminal caspase recruitment domain (CARD) of B-cell CLL/Lymphoma 10 (BCL10). RAIDD has been shown to mediate the recruitment of CASPASE-2 to tumour necrosis factor receptor-1 (TNF-R1) signalling complex through RIP kinase. Apart from its established role in apoptosis, RAIDD may have an additional function in cell differentiation. In developing heart and kidney, RAIDD expression patterns are reported to overlap with known zones of cell death suggesting RAIDD may be involved in apoptosis-mediated remodeling.

特异性

RAIDD Rabbit Recombinant mAb detects endogenous levels of total RAIDD.

背景

Death domain-containing protein CRADD, also known as RAIDD (RIP-associated ICH-1/CED-3- homologous protein with a death domain), induces cell apoptosis. RAIDD negatively regulates NFκB-dependent cytokine and chemokine expression in T cells by targeting the NH2-terminal caspase recruitment domain (CARD) of B-cell CLL/Lymphoma 10 (BCL10). RAIDD has been shown to mediate the recruitment of CASPASE-2 to tumour necrosis factor receptor-1 (TNF-R1) signalling complex through RIP kinase. Apart from its established role in apoptosis, RAIDD may have an additional function in cell differentiation. In developing heart and kidney, RAIDD expression patterns are reported to overlap with known zones of cell death suggesting RAIDD may be involved in apoptosis-mediated remodeling.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human

MW (kDa)

23kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck