Raltegravir potassium

目录号：S5245 批次号：S524501

化学数据

	别名	MK-0518 potassium	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₂₀H₂₀FN₆O₅.K
	分子量	482.51	CAS号	871038-72-1
Solubility (25°C)*	体外	DMSO	96 mg/mL (198.95 mM)
		Ethanol	10 mg/mL (20.72 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

Raltegravir Potassium(MK-0518 potassium)是一种具有口服活性的raltegravir钾盐。Raltegravir是HIV-1 integrase抑制剂。

靶点

HIV integrase ^[2]

参考文献

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Raltegravir potassium在文献中得到引用

The impact of HTLV-1 expression on the 3D structure and expression of host chromatin [ PLoS Pathog, 2024, 20(3):e1011716]	PubMed: 38427693
Inhibition of Adipose Tissue Beiging by HIV Integrase Inhibitors, Dolutegravir and Bictegravir, Is Associated with Adipocyte Hypertrophy, Hypoxia, Elevated Fibrosis, and Insulin Resistance in Simian Adipose Tissue and Human Adipocytes [ Cells, 2022, 11(11)1841]	PubMed: 35681536
Reduction of CD8 T cell functionality but not inhibitory capacity by integrase inhibitors [ J Virol, 2022, JVI0173021]	PubMed: 35019724
Impact of combinations of clinically observed HIV integrase mutations on phenotypic resistance to integrase strand transfer inhibitors (INSTIs): a molecular study [ J Antimicrob Chemother, 2022, dkab498]	PubMed: 35061879
A synthetic resveratrol analog termed Q205 reactivates latent HIV-1 through activation of P-TEFb [ Biochem Pharmacol, 2021, 197:114901]	PubMed: 34971588
The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis [ Elife, 2018, 7e36245]	PubMed: 29941091
[ PLoS Pathog, 2018, ]	PubMed: 29470552
Influence of Biological Sex, Age, and HIV Status in an In Vitro Primary Cell Model of HIV Latency Using a CXCR4 Tropic Virus [ AIDS Res Hum Retroviruses, 2018, 34(9):769-777]	PubMed: 29926732
Vpr Promotes Macrophage-Dependent HIV-1 Infection of CD4+ T Lymphocytes. [ PLoS Pathog, 2015, 11(7):e1005054]	PubMed: 26186441
A multisystem investigation of raltegravir association with intestinal tissue: implications for pre-exposure prophylaxis and eradication. [ J Antimicrob Chemother, 2014, 69(12):3275-81]	PubMed: 25114168

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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