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别名 | Stivarga, BAY 73-4506 hydrochloride | 储存条件 (自收到货起) |
3年 -20°C 粉状 | |
化学式 | C21H16Cl2F4N4O3 |
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分子量 | 519.28 | CAS号 | 835621-07-3 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (192.57 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Regorafenib (Stivarga, BAY 73-4506) Hydrochloride 是一种多靶点抑制剂,对 VEGFR1、Murine VEGFR2/3、PDGFRβ、Kit (c-Kit)、RET (c-RET) 和 Raf-1 的IC50值分别为13 nM、4.2 nM/46 nM、22 nM、7 nM、1.5 nM和2.5 nM。 | |||||||||||
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靶点 |
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Differentiating Benign from Malignant Thyroid Tumors by Kinase Activity Profiling and Dabrafenib BRAF V600E Targeting [ Cancers (Basel), 2023, 15(18)4477] | PubMed: 37760447 |
Differentiating Benign from Malignant Thyroid Tumors by Kinase Activity Profiling and Dabrafenib BRAF V600E Targeting [ Cancers (Basel), 2023, 15(18)4477] | PubMed: 37760447 |
Effect of Intraperitoneal Chemotherapy with Regorafenib on IL-6 and TNF-α Levels and Peritoneal Cytology: Experimental Study in Rats with Colorectal Peritoneal Carcinomatosis [ J Clin Med, 2023, 12(23)7267] | PubMed: 38068319 |
Triple MAPK inhibition salvaged a relapsed post-BCMA CAR-T cell therapy multiple myeloma patient with a BRAF V600E subclonal mutation [ J Hematol Oncol, 2022, 15(1):109] | PubMed: 35978321 |
Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients [ Anticancer Drugs, 2022, 10.1097/CAD.0000000000001344] | PubMed: 36066384 |
Impact of a Desmoplastic Tumor Microenvironment for Colon Cancer Drug Sensitivity: A Study with 3D Chimeric Tumor Spheroids [ ACS Appl Mater Interfaces, 2021, 13(41):48478-48491] | PubMed: 34633791 |
Recapitulating cholangiopathy-associated necroptotic cell death in vitro using human cholangiocyte organoids [ Cell Mol Gastroenterol Hepatol, 2021, S2352-345X(21)00223-X] | PubMed: 34700031 |
Leukotriene receptor antagonists enhance HCC treatment efficacy by inhibiting ADAMs and suppressing MICA shedding [ Cancer Immunol Immunother, 2021, 70(1):203-213] | PubMed: 32683508 |
Entrectinib Induces Apoptosis and Inhibits the Epithelial-Mesenchymal Transition in Gastric Cancer with NTRK Overexpression [ Int J Mol Sci, 2021, 23(1)395] | PubMed: 35008821 |
Autophagy-Related Chemoprotection against Sorafenib in Human Hepatocarcinoma: Role of FOXO3 Upregulation and Modulation by Regorafenib [ Int J Mol Sci, 2021, 22(21)11770] | PubMed: 34769197 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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