Datasheet

生物描述

特异性	Reptin/RUVBL2 Rabbit Recombinant mAb detects endogenous levels of total Reptin/RUVBL2.
背景	Reptin (also called RUVBL2) belongs to the AAA+ (ATPases associated with diverse cellular activities) superfamily of ATPases. Reptin has been associated with many biological processes, such as chromatin remodelling, transcription regulation and stabilisation of all members of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family, including mTOR (mechanistic target of rapamycin). Reptin interacts with transcription factors, including β-catenin and c-Myc. It is demonstrated that reptin directly interacts with the PCD protein Lrrc6/Seahorse and this interaction is critical for the in vivo function of Lrrc6/Seahorse in zebrafish, suggesting that reptin functions in both cilia specific and cilia independent in vertebrate development. Reptin is also a regulator of mTOR signalling in the liver and global glucido-lipidic homeostasis. Reptin is essential for sustaining the hyperproliferative state and clonogenic potential, as well as suppressing apoptosis, of human AML cells, both MLL-rearranged and non-MLL rearranged.

特异性

Reptin/RUVBL2 Rabbit Recombinant mAb detects endogenous levels of total Reptin/RUVBL2.

背景

Reptin (also called RUVBL2) belongs to the AAA+ (ATPases associated with diverse cellular activities) superfamily of ATPases. Reptin has been associated with many biological processes, such as chromatin remodelling, transcription regulation and stabilisation of all members of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family, including mTOR (mechanistic target of rapamycin). Reptin interacts with transcription factors, including β-catenin and c-Myc. It is demonstrated that reptin directly interacts with the PCD protein Lrrc6/Seahorse and this interaction is critical for the in vivo function of Lrrc6/Seahorse in zebrafish, suggesting that reptin functions in both cilia specific and cilia independent in vertebrate development. Reptin is also a regulator of mTOR signalling in the liver and global glucido-lipidic homeostasis. Reptin is essential for sustaining the hyperproliferative state and clonogenic potential, as well as suppressing apoptosis, of human AML cells, both MLL-rearranged and non-MLL rearranged.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse

MW (kDa)

48kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck