Retinoic Acid Receptor beta Rabbit Recombinant mAb

生物描述

特异性

Retinoic Acid Receptor beta Rabbit Recombinant mAb detects endogenous level of total Retinoic Acid Receptor beta.

背景

Retinoids, the natural and synthetic vitamin A derivatives, are known to regulate a broad range of biological processes, including growth, differentiation, and development. The effects of retinoids are mainly mediated by two classes of nuclear receptors: the retinoic acid (RA) receptors (RARs) and the retinoid X receptors (RXRs). RARs and RXRs are members of the steroid-thyroid hormone receptor superfamily that also includes receptors for estrogen and vitamin D. Three RAR subtypes [RARα, RARβ, and RARγ] that originate from three distinct genes have been identified. RARβ consists of four isoforms that arise from the differential usage of two promoters and alternative splicing, which display unique expression patterns both in the embryo and in the adult. The expression of RARβ is frequently lost in many neoplastic tissues, including non-small cell lung cancer, squamous cell carcinomas of the head and neck, and breast cancer, and its expression correlates inversely with tumor grade.

使用信息

抗体应用	WB, IHC, IF,ELISA,ELISA
稀释比例	WB IHC IF 1:1000 1:50 1:50
反应性	Human
MW (kDa)	55kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Y Liu, et al. Mol Cell Biol. 1996, 16(3): 1138–1149. [2] Alvarez S, et al. Int J Biochem Cell Biol. 2007, 39(7-8):1406-15.

Application Data

WB

IHC

IF