Ribociclib succinate

目录号：S5188 批次号：S518801

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化学数据

化学结构式 别名 LEE011 succinate 储存条件
(自收到货起)		 3年 -20°C 粉状
化学式

C27H36N8O5
分子量 552.63 CAS号 1374639-75-4
Solubility (25°C)* 体外 DMSO 100 mg/mL (180.95 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 Ribociclib (LEE011) succinate是一种高度特异性的针对 CDK4 和 CDK6 的双重抑制剂，对应的IC50值分别为10 nM和39 nM。
靶点
CDK4 [1]
(Cell-free assay)		 CDK6 [1]
(Cell-free assay)
10 nM 39 nM

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

Ribociclib succinate在文献中得到引用

Internally Controlled and Dynamic Optical Measures of Functional Tumor Biology [ Anal Chem, 2023, 95(13):5661-5670] PubMed: 36952386
Overexpressed Cyclin D1 and CDK4 proteins are responsible for the resistance to CDK4/6 inhibitor in breast cancer that can be reversed by PI3K/mTOR inhibitors [ Sci China Life Sci, 2022, 10.1007/s11427-021-2140-8] PubMed: 35982377
Genome wide CRISPR/Cas9 screen identifies the coagulation factor IX (F9) as a regulator of senescence [ Cell Death Dis, 2022, 13(2):163] PubMed: 35184131
MYC promotes tyrosine kinase inhibitor resistance in ROS1 fusion-positive lung cancer [ Mol Cancer Res, 2022, molcanres.MCR-22-0025-E.2022] PubMed: 35149545
Treatment of Retinoblastoma 1-Intact Hepatocellular Carcinoma With Cyclin-Dependent Kinase 4/6 Inhibitor Combination Therapy [ Hepatology, 2021, 74(4):1971-1993] PubMed: 33931882
Development and Characterization of Novel Endoxifen-Resistant Breast Cancer Cell Lines Highlight Numerous Differences from Tamoxifen-Resistant Models [ Mol Cancer Res, 2021, 19(6):1026-1039] PubMed: 33627502
Inhibition of CDK4/6 kinases causes production of aneuploid oocytes by inactivating the spindle assembly checkpoint and accelerating first meiotic progression [ Biochim Biophys Acta Mol Cell Res, 2021, 1868(7):119044] PubMed: 33865884
Targeting WEE1 Inhibits Growth of Breast Cancer Cells That Are Resistant to Endocrine Therapy and CDK4/6 Inhibitors [ Front Oncol, 2021, 11:681530] PubMed: 34277427
Molecular targeted drugs resistance impairs double-strand break repair and sensitizes ER-positive breast cancer to PARP inhibitors [ Breast Cancer, 2021, 10.1007/s12282-021-01282-5] PubMed: 34346034
Genomic Resistance Patterns to Second-Generation Androgen Blockade in Paired Tumor Biopsies of Metastatic Castration-Resistant Prostate Cancer [ JCO Precis Oncol, 2017, 1PO.17.00140] PubMed: 32913968

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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