Datasheet

生物描述

特异性	RNF20 Rabbit Recombinant mAb detects endogenous levels of total RNF20.
背景	Monoubiquitylation of histone H2B is a post-translational mark that plays key roles in regulation of transcription and genome stability. In humans, attachment of ubiquitin to lysine 120 of histone H2B depends on the activity of the E2 ubiquitin-conjugating enzyme, Ube2B, and the really interesting new gene (RING) E3 ligases, RING finger protein (RNF) 20 and RNF40. RNF20 has long been associated with the progression of mixed lineage leukemia (MLL) and with the development of breast, colorectal, and lung tumors. RNF20 and RNF40 are active dimeric RING E3 ligases. RNF20 is a candidate tumor suppressor, exerting its effects via selective modulation of defined subsets of genes possessing distinct chromatin features.

特异性

RNF20 Rabbit Recombinant mAb detects endogenous levels of total RNF20.

背景

Monoubiquitylation of histone H2B is a post-translational mark that plays key roles in regulation of transcription and genome stability. In humans, attachment of ubiquitin to lysine 120 of histone H2B depends on the activity of the E2 ubiquitin-conjugating enzyme, Ube2B, and the really interesting new gene (RING) E3 ligases, RING finger protein (RNF) 20 and RNF40. RNF20 has long been associated with the progression of mixed lineage leukemia (MLL) and with the development of breast, colorectal, and lung tumors. RNF20 and RNF40 are active dimeric RING E3 ligases. RNF20 is a candidate tumor suppressor, exerting its effects via selective modulation of defined subsets of genes possessing distinct chromatin features.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse

MW (kDa)

114kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck